Multipotent fetal stem cells in reproductive biology research - Stem Cell Research & Therapy

Amniotic fluid

AFSCs

Human AFSCs injected into busulfan-induced POF mice restored ovarian morphology and functions

Female

[215]

Rat AFSCs mediated therapeutic effects on busulfan-induced azoospermia in rats

Male

[234]

AF-MSCs

Human AF-MSCs improved ovarian function in a physiological aging mouse model

Female

[235]

Human AF-MSCs-derived exosomes exerted positive effects on ovarian granulosa cells in a mouse POF model

Female

[171]

Amniotic membrane

AM-MSCs

Human AM-MSCs recovered ovarian function in a chemical-induced premature ovarian aging mouse model

Female

[236]

Ultrasound-pretreated AM-MSCs transplantation increased reproductive organ weight and improved ovarian function in POI rats

Female

[237]

Human AM-MSCs exerted a therapeutic activity in a natural ovarian aging mouse model (improving follicle numbers)

Female

[172]

Human AM-MSCs injected into tail veins improved ovarian functions in a rat POI model

Female

[238]

Human AM-MSCs recovered ovarian function in a mouse POF model

Female

[166]

Human AM-MSCs transplanted into mouse testis upon busulfan-induced toxicity restored spermatogenesis

Male

[239]

Tail vein or ovary injection of human AM-MSCs improved ovarian function in rats with chemotherapy-induced POI

Female

[165]

Human AM-MSCs facilitated injured endometrial regeneration in a rat intrauterine adhesions model

Female

[178]

AECs

Human AECs recovered ovarian function in a chemical-induced premature ovarian aging mouse model

Female

[236]

Injection of human AECs and AEC-conditioned medium into mouse ovaries protected against chemotherapy-induced damage

Female

[240]

Human AEC-derived exosomes restored ovarian function in chemotherapy-induced POF mice by transferring microRNAs

Female

[241]

Wharton´s jelly

WJ-MSCs

Injection of human WJ-MSCs into testis of chemically induced azoospermic mice induced murine germ cell differentiation

Male

[242]

Human WJ-MSCs differentiated into germ-like cells upon injection into mouse seminiferous tubules

Male

[161]

Intraperitoneal injection of WJ-MSCs mediated therapeutic effects on oviduct function and fertility in rats with salpingitis

Female

[175]

Human WJ-MSCs recovered disturbed hormone secretion and folliculogenesis in a rat POF model

Female

[243]

Tail vein-injected human WJ-MSCs improved the reserve function of perimenopausal rat ovaries via paracrine mechanisms

Female

[162]

Transplantation of human WJ-MSCs in rabbits with chronic salpingitis partially restored fertility

Female

[244]

Human WJ-MSCs-derived exosomes improved POI related to ovarian granulosa cell apoptosis caused by cisplatin chemotherapy

Female

[245]

WJ-MSCs exhibited homing characteristics and migrated to injured oviducts in rabbit to promote epithelial cell growth

Female

[174]

In a human phase I clinical trial intrauterine injection of WJ-MSCs increased the pregnancy rate in Asherman adhesion syndromes

Female

[179]

Therapeutic effect of human WJ-MSCs on tubal factor infertility in a chronic salpingitis murine model

Female

[176]

Microvesicles derived from human WJ-MSCs mediated therapeutic effects in a mouse POF model

Female

[246]

Tail vein injection of human WJ-MSCs prevented chemotherapy-induced ovarian failure in rats

Female

[163]

WJ-MSCs regulated ovarian stromal cell differentiation via TGFβ1 and repaired ovarian function in POI rats

Female

[168]

Transplantation of human WJ-MSCs improved ovarian function in a rat model of autoimmune-induced POF

Female

[247]

Extracellular vesicles derived from human WJ-MSCs recovered fertility of premature ovarian insufficiency mice

Female

[248]

Tail vein-injected human WJ-MSCs repaired chemotherapy-induced POF in mice

Female

[164]

Protective effects of human WJ-MSC-derived conditioned medium on a cisplatin-induced ovarian injury mouse model

Female

[249]

Injection of human WJ-MSCs in the ovary tissue of POF rats increased the amount of ovarian follicles

Female

[250]

Umbilical cord blood

UCB-MSCs

Injection of human UCB-MSCs into chemotherapeutic-induced azoospermic mice improved spermatogenesis

Male

[251]

Human UCB-MSCs restored fertility in chemotherapy-induced POI mice

Female

[252]

Administration of human UCB-MSCs improved degenerative changes in the follicles of CTX-induced POF mice

Female

[253]

Placenta

CP-MSCs

3D-cultured human CP-MSC-spheroids enhanced ovarian function by inducing folliculogenesis

Female

[254]

Transplanted human CP-MSCs restored ovarian function in chemotherapy-treated mice

Female

[255]

Human CP-MSCs inhibited apoptosis of granulosa cells in autoimmune POF mice

Female

[256]

CP-MSC-mediated antioxidant effects restored ovarian function in an ovariectomized rat model

Female

[257]

Human CP-MSCs stimulated ovarian function in aged rats

Female

[169]

EGF released from human CP-MSCs improved POI in a mouse model

Female

[170]

Human CP-MSCs restored ovarian function and induced ovarian folliculogenesis in ovariectomized rats

Female

[167]

Human CP-MSCs ameliorated chemotherapy-induced damage in mouse testis

Male

[258]

Vascular remodeling by human CP-MSCs restored ovarian function in an ovariectomized rat model

Female

[173]

CV-MSCs

EGF released from human CV-MSCs improved POI in a mouse model

Female

[170]

Human CV-MSCs ameliorated chemotherapy-induced damage in mouse testis

Male

[258]