CYTH2

CYTH2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1PBV, 1R8M, 1R8Q, 1R8S, 1S9D, 4JMI, 4JMO, 4JWL, 4JXH, 4L5M, 4Z21
Identifiers
Aliases	CYTH2, ARNO, CTS18, CTS18.1, PSCD2, PSCD2L, SEC7L, Sec7p-L, Sec7p-like, cytohesin 2, cytohesin-2
External IDs	OMIM: 602488; MGI: 1334255; HomoloGene: 32116; GeneCards: CYTH2; OMA:CYTH2 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.33 Start 48,469,208 bp[1] End 48,482,314 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 B3 Start 45,456,061 bp[2] End 45,464,005 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence left testis right testis frontal pole right lobe of thyroid gland left lobe of thyroid gland paraflocculus of cerebellum Brodmann area 10 middle frontal gyrus ventricular zone Top expressed in neural layer of retina ganglionic eminence medial ganglionic eminence ventricular zone dentate gyrus of hippocampal formation granule cell neural tube spermatid seminiferous tubule superior frontal gyrus granulocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function inositol 1,4,5 trisphosphate binding protein binding guanyl-nucleotide exchange factor activity lipid binding Cellular component cytoplasm growth cone plasma membrane cell projection membrane Golgi membrane cytosol adherens junction bicellular tight junction cell junction Biological process regulation of ARF protein signal transduction endocytosis actin cytoskeleton organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9266 19158 Ensembl ENSG00000105443 ENSMUSG00000003269 UniProt Q99418 P63034 RefSeq (mRNA) NM_004228 NM_017457 NM_001112701 NM_011181 RefSeq (protein) NP_004219 NP_059431 NP_001106171 NP_035311 Location (UCSC) Chr 19: 48.47 – 48.48 Mb Chr 7: 45.46 – 45.46 Mb PubMed search [3] [4]
Wikidata
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Cytohesin-2 is a protein that in humans is encoded by the CYTH2 gene.^[5][6][7]

Cytohesin-2 (CYTH2), formerly known as Pleckstrin homology, Sec7 and coiled/coil domains 2 (PSCD2), is a member of the cytohesin family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of CYTHs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. CYTH2 exhibits GEP activity in vitro with ARF1, ARF3, and ARF6. CYTH2 protein is 83% homologous to CYTH1. Two transcript variants encoding different isoforms have been found for this gene.^[7]

CYTH2 has been shown to interact with Arrestin beta 2^[8] and Arrestin beta 1. ^[8]