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Ltf MGI Mouse Gene Detail - MGI:96837 - lactotransferrin

Summary

Symbol

Ltf
Name

lactotransferrin
Synonyms

lactoferrin, Lf

Feature Type

protein coding gene
IDs

MGI:96837
NCBI Gene: 17002
Alliance
Transcription Start Sites

17 TSS

Location &
Maps

Sequence Map

Chr9:110848360-110871834 bp, + strand
From NCBI annotation of GRCm39
Genome Browsers

Genetic Map

Chromosome 9, 60.79 cM, cytoband F
Mapping Data

7 experiments

Strain
Comparison

SNPs within 2kb

901 from dbSNP Build 142
Strain Annotations

18

Homology

Human Ortholog

LTF, lactotransferrin

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LTF, lactotransferrin
Synonyms

GIG12, HEL110, HLF2, LF
Links
Chr Location

3p21.31; chr3:46435645-46485234 (-) GRCh38

MGI Vertebrate Homology
HCOP

vertebrate homology predictions: LTF
Protein SuperFamily
Gene Tree

Human Diseases

Diseases

3 with human LTF associations

Mutations,
Alleles, and
Phenotypes

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Phenotype Summary

9 phenotypes from 3 alleles in 3 genetic backgrounds
13 phenotypes from multigenic genotypes
2 images
40 phenotype references

Phenotype Overview

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles
Endonuclease-mediated
Targeted
Incidental Mutations
Find Mice (IMSR)
Comparison Matrix
Recombinase Activity

Mice homozygous for a knock-out allele are viable, fertile, and grossly normal and exhibit only minor alterations in iron homeostasis. Mice homozygous for a different knock-out allele show increased susceptibility to inflammation-induced colorectal dysplasia along with increased cell proliferation and decreased apoptosis in colonic tissues.

Gene Ontology
(GO)
Classifications

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All GO Annotations
GO References

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

Expression

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Expression Overview

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results
Tissues
cDNA Data
Literature Summary

Other Mouse Links
Other Vertebrate Links

GEISHA TF

Sequences &
Gene Models

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All Sequences
RefSeq
UniProt
CCDS

Ensembl
NCBI Gene

Protein
Information

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UniProt

14 Sequences
Protein Ontology
EC
InterPro Domains

IPR018195 Transferrin family, iron binding site
GlyGen

P08071 2 sites, 1 N-linked glycan (1 site)

Molecular
Reagents

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Genomic 11

Primer pair 6

Microarray probesets 3

References

Summaries

Developmental Gene Expression 21

Gene Ontology 9

Phenotypes 40
Earliest

J:8905 Teng CT, et al., Assignment of the lactotransferrin gene to human chromosome 3 and to mouse chromosome 9. Somat Cell Mol Genet. 1987 Nov;13(6):689-93
Latest

J:338821 Li R, et al., TRIM28 modulates nuclear receptor signaling to regulate uterine function. Nat Commun. 2023 Aug 1;14(1):4605