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KEGG ENZYME: 1.11.1.8

Entry

EC 1.11.1.8 Enzyme

Name

iodide peroxidase;
thyroid peroxidase;
iodoperoxidase (heme type);
iodide peroxidase-tyrosine iodinase;
thyroperoxidase;
tyrosine iodinase;
TPO;
iodinase

Class

Oxidoreductases;
Acting on a peroxide as acceptor;
Peroxidases

Sysname

iodide:hydrogen-peroxide oxidoreductase

Reaction(IUBMB)

(1) 2 iodide + H2O2 + 2 H+ = diiodine + 2 H2O [RN:R02810];
(2) [thyroglobulin]-L-tyrosine + iodide + H2O2 = [thyroglobulin]-3-iodo-L-tyrosine + 2 H2O;
(3) [thyroglobulin]-3-iodo-L-tyrosine + iodide + H2O2 = [thyroglobulin]-3,5-diiodo-L-tyrosine + 2 H2O;
(4) 2 [thyroglobulin]-3,5-diiodo-L-tyrosine + H2O2 = [thyroglobulin]-L-thyroxine + [thyroglobulin]-aminoacrylate + 2 H2O [RN:R08523];
(5) [thyroglobulin]-3-iodo-L-tyrosine + [thyroglobulin]-3,5-diiodo-L-tyrosine + H2O2 = [thyroglobulin]-3,5,3'-triiodo-L-thyronine + [thyroglobulin]-aminoacrylate + 2 H2O [RN:R08522]

Reaction(KEGG)

R02810 R08522 R08523;
(other) R03208 R03539 R03953 R03973 R08520 R08521

Substrate

iodide [CPD:C00708];
H2O2 [CPD:C00027];
H+ [CPD:C00080];
[thyroglobulin]-L-tyrosine [CPD:C16733];
[thyroglobulin]-3-iodo-L-tyrosine [CPD:C16732];
[thyroglobulin]-3,5-diiodo-L-tyrosine [CPD:C16731]

Product

diiodine [CPD:C01382];
H2O [CPD:C00001];
[thyroglobulin]-3-iodo-L-tyrosine [CPD:C16732];
[thyroglobulin]-3,5-diiodo-L-tyrosine [CPD:C16731];
[thyroglobulin]-L-thyroxine [CPD:C16729];
[thyroglobulin]-aminoacrylate [CPD:C16734];
[thyroglobulin]-3,5,3'-triiodo-L-thyronine [CPD:C16730]

Comment

Thyroid peroxidase catalyses the biosynthesis of the thyroid hormones L-thyroxine and triiodo-L-thyronine. It catalyses both the iodination of tyrosine residues in thyroglobulin (forming mono- and di-iodinated forms) and their coupling to form either L-thyroxine or triiodo-L-thyronine.

History

EC 1.11.1.8 created 1961, modified 2012

Pathway

ec00350

Tyrosine metabolism

ec01100

Metabolic pathways

Orthology

K00431

thyroid peroxidase

Genes

HSA:

7173(TPO)

PTR:	112208205(TPO)

PPS:	100996140(TPO)

GGO:	101154382(TPO)

PON:	100456793(TPO)

PPYG:

129030203(TPO)

NLE:	100600125(TPO) 115834294

HMH:	116480453(TPO)

SSYN:

129468214(TPO)

MCC:	721610(TPO)

MCF:	102125126(TPO)

MTHB:

126933457

MNI:	105497560(TPO)

CSAB:

103220948(TPO)

CATY:

105587598(TPO)

PANU:

101002980(TPO)

TGE:	112604644(TPO)

MLEU:

105546350(TPO)

RRO:	104680243(TPO)

RBB:	108520786(TPO)

TFN:	117062801(TPO)

PTEH:

111526756(TPO)

CANG:

105525386(TPO)

CJC:	100386952(TPO)

SBQ:	101037216(TPO)

CIMI:

108292902(TPO)

ANAN:

110567902(TPO)

CSYR:

103263957(TPO)

MMUR:

105870505(TPO)

LCAT:

123636559(TPO)

PCOQ:

105824646(TPO)

OGA:	100950962(TPO)

MMU:	22018(Tpo)

MCAL:

110307221(Tpo)

MPAH:

110324682(Tpo)

RNO:	54314(Tpo)

MCOC:

116080994(Tpo)

ANU:	117717370(Tpo)

ASYL:

127687959(Tpo)

MUN:	110561242(Tpo)

CGE:	100774668(Tpo)

MAUA:

101838356(Tpo)

PROB:

127234369(Tpo)

PLEU:

114683239(Tpo)

MORG:

121432305(Tpo)

MFOT:

126491107

AAMP:

119807272(Tpo)

NGI:	103747657(Tpo)

HGL:	101704548(Tpo)

CPOC:

100723704(Tpo)

CCAN:

109698840(Tpo)

DORD:

105995174(Tpo)

DSP:	122100091(Tpo)

PLOP:

125356021(Tpo)

NCAR:

124962925

MMMA:

107137072(Tpo)

ITI:	101976264(Tpo)

OCU:	100358662 127486836

OPI:	101529357(TPO)

TUP:	102498362(TPO)

GVR:	103595081(TPO)

CFA:	403521(TPO)

CLUD:

112664926(TPO)

VVP:	112927779(TPO)

VLG:	121491902(TPO)

NPO:	129511138(TPO)

AML:	100482359(TPO)

UMR:	103659385(TPO)

UAH:	113269244(TPO)

UAR:	123786594(TPO)

ELK:

111154148

LLV:

125108840

MPUF:

101677724(TPO)

MNP:	132021091(TPO)

MLK:	131807442(TPO)

NVS:	122915502(TPO)

ORO:	101386003(TPO)

EJU:	114206012(TPO)

ZCA:	113937469(TPO)

MLX:	118007270 118007322

NSU:	110587338(TPO)

LWW:	102736066(TPO)

FCA:	101098706(TPO)

PYU:	121044026(TPO)

PCOO:

112864369(TPO)

PBG:	122467124(TPO)

PVIV:

125158263(TPO)

LRUF:

124525761

PTG:	102968585(TPO)

PPAD:

109258749(TPO)

PUC:

125937367

AJU:

106970832

HHV:	120247915(TPO)

BTA:	525013(TPO)

BOM:	102270919(TPO)

BBUB:

102407971(TPO)

BBIS:

104994785(TPO)

CHX:	102182976(TPO)

OAS:	105606468(TPO)

BTAX:

128052765(TPO)

CSUM:

138080824(TPO)

ODA:	120864488(TPO)

CCAD:

122432081(TPO)

MREE:

136176341(TPO)

OVR:	110141220(TPO)

MBEZ:

129557445(TPO)

SSC:	445522(TPO)

CFR:	102509347(TPO)

CBAI:

105075311(TPO)

CDK:	105105788(TPO)

VPC:	102531846(TPO)

BACU:

103019738(TPO)

BMUS:

118905807(TPO)

LVE:	103068590(TPO)

OOR:	101277595(TPO)

DLE:	111167991(TPO)

PCAD:

102992243(TPO)

PSIU:

116764397(TPO)

NASI:

112407583(TPO)

ECB:	100072955(TPO)

EPZ:	103558875(TPO)

EAI:	106831426(TPO)

MYB:	102261673(TPO)

MYD:	102752073(TPO)

MMYO:

118669324(TPO)

MDT:	132213679(TPO)

PKL:	118714838(TPO)

EFUS:

103283185(TPO)

MNA:	107526670(TPO)

DRO:	112298003(TPO)

SHON:

118988799(TPO)

AJM:	119053969(TPO)

PDIC:

114498752(TPO)

PHAS:

123822481(TPO)

MMF:	118630987(TPO)

PPAM:

129065568(TPO)

HAI:	109384713(TPO)

RFQ:	117032670(TPO)

PALE:

102894645(TPO)

PGIG:

120596537(TPO)

PVP:	105306937(TPO)

RAY:	107516248(TPO)

MJV:	108410043(TPO)

TOD:	119258688(TPO)

SARA:

101544834(TPO)

SFUM:

130034800(TPO)

SETR:

126024250(TPO)

LAV:	100654315(TPO)

TMU:

101356790

ETF:	101650056(TPO)

DNM:	101411611(TPO)

MDO:	100032350(TPO)

GAS:	123233464(TPO)

SHR:	100914346(TPO)

AFZ:

127546516

PCW:	110193820(TPO)

TVP:	118844045(TPO)

PBRV:

138177497(TPO)

OAA:	100080616(TPO)

TACU:

119949810(TPO)

GGA:	776120(TPO)

PCOC:

116240489(TPO)

MGP:	100547103(TPO)

CJO:	107312163(TPO)

TPAI:

128087649(TPO)

LMUT:

125689477(TPO)

NMEL:

110396710(TPO)

APLA:

101799650(TPO)

ACYG:

106030804(TPO)

CATA:

118246103(TPO)

AFUL:

116487946(TPO)

TGU:	100218312(TPO)

LSR:	110482186(TPO)

SCAN:

103822861(TPO)

PMOA:

120505263(TPO)

OTC:	121344293(TPO)

PRUF:

121359149(TPO)

GFR:	102035753(TPO)

FAB:	101810932(TPO)

OMA:	130250535(TPO)

PHI:	102101957(TPO)

PMAJ:

107202328(TPO)

CCAE:

111926044(TPO)

CCW:	104685517(TPO)

CBRC:

103622838(TPO)

ACOE:

138108610(TPO)

ETL:	114069616(TPO)

ZAB:	102067657(TPO)

ZLE:	135446359(TPO)

ACHL:

103798919(TPO)

SVG:	106849075(TPO)

MMEA:

130576566(TPO)

HRT:	120750049(TPO)

SATI:

136358333(TPO)

FPG:	101922364(TPO)

FCH:	102045733(TPO)

CCRI:

104164426(TPO)

SHAB:

115609450(TPO)

ACUN:

113477604(TPO)

TALA:

104359736(TPO)

ACHC:

115351124(TPO)

HALD:

104315049(TPO)

HLE:	104831289(TPO)

AGEN:

126046400

HHAR:

128152043(TPO)

GCL:

127014894

LDI:	104351831(TPO)

MNB:	103777585(TPO)

DPUB:

104305690(TPO)

PPUS:

135177071(TPO)

AVIT:

104270482(TPO)

BRHI:

104489655(TPO)

EGZ:	104122160(TPO)

NNI:	104013841(TPO)

PCRI:

104032438

PCAO:

104047200

PADL:

103921358(TPO)

AFOR:

103895897(TPO)

FGA:	104079472(TPO)

GSTE:

104252217(TPO)

CLV:	102095211(TPO)

MUI:	104533545(TPO)

PGUU:

104469372(TPO)

PLET:

104625294

EHS:	104504514(TPO)

CUCA:

104064875(TPO)

TEO:	104380949(TPO)

OHA:	104329380(TPO)

ACAR:

104529229(TPO)

CPEA:

104390153(TPO)

CVF:	104289037(TPO)

RTD:	128907817(TPO)

AAM:	106492987(TPO)

AROW:

112973093(TPO)

NPD:	112945458(TPO)

TGT:	104580334(TPO)

DNE:	112992818(TPO)

SCAM:

104143498(TPO)

ASN:	102375780(TPO)

AMJ:	106736998(TPO)

CPOO:

109312104(TPO)

GGN:	109300041(TPO)

PSS:	102447524(TPO)

CMY:	102940210(TPO)

CCAY:

125635012(TPO)

DCC:	119853278(TPO)

CPIC:

101932866(TPO)

TST:	117874041(TPO)

CABI:

116817604(TPO)

MRV:	120401415(TPO)

ACS:	100562991(tpo)

ASAO:

132773157(TPO)

PVT:	110073409(TPO)

SUND:

121925349(TPO)

PBI:	103055216(TPO)

PMUR:

107288276(TPO)

CTIG:

120310082(TPO)

TSR:	106551315(TPO)

PGUT:

117674498(TPO)

APRI:

131195643(TPO)

PTEX:

113455290(TPO)

NSS:	113410540(TPO)

VKO:	123017669(TPO)

PMUA:

114593754(TPO) 114600521

PRAF:

128410067(TPO) 128417614

ZVI:	118078350 118082781(TPO)

HCG:	128339342 128340645(TPO)

GJA:	107108843 107120374(TPO)

STOW:

125426778 125439527(TPO)

EMC:	129323482 129324144(TPO)

XLA:	100049788(tpo.S)

XTR:	100036738(tpo)

NPR:	108789262(TPO)

RTEM:

120936386(TPO)

BBUF:

120999023(TPO)

BGAR:

122935226(TPO)

MUO:	115464797(TPO)

GSH:	117357180(TPO)

DRE:	100331172(epx) 569363(tpo)

SRX:	107707791(tpo) 107732259

SANH:

107676453 107678715(tpo) 107701038

SGH:

107594129

CCAR:

109084952 109099142

CAUA:

113042938 113085118(tpo)

CGIB:

128013963 128031820

PTET:

122330629(epx) 122334382(tpo)

LROH:

127156758(epx) 127179243(tpo)

OMC:	131523159(tpo) 131534985(epx)

PPRM:

120471728(epx) 120473217 120473261

RKG:	130075798(tpo) 130106479(epx)

MAMB:

125247940(epx) 125269309(tpo)

CIDE:

127498092 127507673

CERY:

137006300(tpo) 137015584(epx)

MASI:

127435674 127455176

TROS:

130550078(epx) 130559836 130560167

TDW:	130414644(epx) 130436790(tpo)

MANU:

129417025(tpo) 129433472(epx)

IPU:	108269580 108274988(epx)

IFU:	128612578(tpo) 128617734(epx)

PHYP:

113529680 113538844(tpo)

SMEO:

124389670(tpo) 124392946(epx)

TFD:	113653966(epx) 113659460(tpo)

TVC:	132852534(tpo) 132856864(epx)

TRN:	134321707(epx) 134325721(tpo)

AMEX:

103026466(epx) 103032699(tpo)

CMAO:

118811861(epx) 118823206(tpo)

EEE:	113572650(tpo) 113583564

CHAR:

105892418(epx) 105909411(tpo)

SPIL:

134068056(tpo) 134093465(epx)

TRU:	101062981 101079869 115247027

TFS:	130536010(epx) 130540092(tpo)

TNG:	GSTEN00010284G001 GSTEN00012455G001

LCO:	104928854 104934649(tpo)

NCC:

104944637

TBEN:

117486655 117491490(epx)

CGOB:

115009405 115027547(tpo)

PGEO:

117448489 117468095(tpo)

GACU:

117538992(epx) 117542389

EMAC:

134879856(epx) 134882017(tpo)

ELY:	117261785(epx) 117267275

EFO:	125886852(epx) 125901384(tpo)

PLEP:

121950093(epx) 121953636(tpo)

SLUC:

116038497(epx) 116042521(tpo)

ECRA:

117935626(tpo) 117949679(epx)

ESP:	116669921(tpo) 116694341

PFLV:

114547036(tpo) 114560272

GAT:	120808678(epx) 120832611(tpo)

PPUG:

119195992(epx) 119227498(tpo)

AFB:	129107865(epx)

CLUM:

117731997(epx) 117751548(tpo)

PSWI:

130195613(epx) 130201641

CANA:

137803730(epx)

CVE:	137877949 137881678(epx)

MSAM:

119893789(epx) 119910842(tpo)

SCHU:

122862127(tpo) 122875391(epx)

CUD:	121514495(epx) 121526598

SPUL:

138591245(tpo) 138612682(epx)

LMIX:

132972597(epx) 132993189(tpo)

ALAT:

119005006(tpo) 119024167(epx)

ASTR:

137593770(epx) 137611202(tpo)

MZE:	101470734(tpo) 101472649

ONL:	100692514 100700906(tpo)

OAU:	116326276(epx) 120434955(tpo)

OLA:	101167362 105356959(tpo)

OML:	112143527(tpo) 112152280(epx)

CSAI:

133444161(epx) 133462180

XMA:	102230399 102232241

XCO:	114134369 114151183

XHE:	116709035 116709593 116732146

PRET:

103460527 103466494

PFOR:

103141318 103154181(tpo)

PLAI:

106953134(tpo) 106964663

PMEI:

106923933(tpo) 106933097

GAF:	122835368(epx) 122845674(tpo)

PPRL:

129369558(epx) 129374765

CVG:

107100628

CTUL:

119787434(epx) 119797839(tpo)

GMU:	124858077(epx) 124884924(tpo)

NFU:	107388669 107392598(tpo)

KMR:	108230067(epx) 108241739(tpo)

ALIM:

106521174 106521219(tpo)

NWH:	119416466(epx) 119427722(tpo)

AOCE:

111562581(tpo) 111584102

EJA:	138206282(epx) 138212549(tpo)

BFRE:

138626549(epx) 138633479(tpo)

MCEP:

125014719(epx) 125023792(tpo)

CSEM:

103379991(tpo) 103380299

POV:	109624077 109627948(tpo)

SSEN:

122776537(epx) 122783162(tpo)

HHIP:

117756338 117762621(epx)

HSP:	118109462(epx) 118116664(tpo)

PPLT:

128444133(epx) 128450360(tpo)

SMAU:

118286573(sntg2) 118315245(epx)

LCF:	108886978(epx) 108897943

SDU:	111226032(tpo) 111229744

SLAL:

111666321 111666895 111670224(tpo)

XGL:	120792877(epx) 120795322(tpo)

HCQ:	109507502 109530238

SSCV:

125970095(epx) 125981320(tpo)

SBIA:

133501708(epx) 133513472(tpo)

PEE:	133402397(epx) 133412463(tpo)

PTAO:

133478512(epx) 133487880(tpo)

BPEC:

110155374(tpo) 110169467

MALB:

109965011(tpo) 109972931

BSPL:

114848308(tpo) 114857330(epx)

SJO:	128359350(epx)

SSCO:

133982501(epx) 134000449(tpo)

SASA:

106584777 106611389(tpo)

STRU:

115161765 115192923

OTW:	112237628(epx) 112256946(tpo)

OMY:	110504252(tpo) 110522697(epx)

OGO:	124037374(epx) 124046982(tpo)

ONE:

115121024

OKI:	109881152 109904614

OKE:	118369032(tpo) 118377954(epx)

OMM:	135526888(tpo) 135533365(epx)

SALP:

112069494(tpo) 112070266

SNH:	120022964 120022991 120051654(epx)

CCLU:

121540756(epx) 121544226(tpo)

ELS:	105028745(tpo) 105029701

SFM:	108942507(tpo)

PKI:	111848005 111857914(tpo)

AANG:

118215539(epx) 118234749(tpo)

AROT:

135241772(epx) 135252679(tpo)

CCOG:

133111088(epx) 133122436(tpo)

LOC:	102695049(tpo)

PSPA:

121294970(epx) 121317659(tpo)

ARUT:

117411246(tpo) 117432329(epx)

PSEX:

120526592(tpo)

LCM:	102362813(TPO)

CMK:	103175078 103185975(tpo)

RTP:	109918711(tpo) 109928222

CPLA:

122548625(tpo) 122557877

HOC:	132824289 132835956(tpo)

LERI:

129696869(tpo) 129705776

PMRN:

116945253(TPO)

LRJ:	133353287(TPO)

CIN:	100183311 100183818 445593

SCLV:

120346294

TCF:	131881866 131882001 131882614 131891773

PMEO:

129593455

CVN:	111102674 111110753

AIRR:

138314855

LJP:

135477769

HSY:

130614431

PFLA:

Pflav_004530

» show all

Reference

1 [PMID:13718859]

Authors

CUNNINGHAM BA, KIRKWOOD S.

Title

Enzyme systems concerned with the synthesis of monoiodotyrosine. III. Ion requirements of the soluble system.

Journal

J Biol Chem 236:485-9 (1961)

Reference

2 [PMID:13964156]

Authors

HOSOYA T, KONDO Y, UI N.

Title

Peroxidase activity in thyroid gland and partial purification of the enzyme.

Journal

J Biochem 52:180-9 (1962)
DOI:10.1093/oxfordjournals.jbchem.a127594

Reference

3 [PMID:12325367]

Authors

Coval ML, Taurog A.

Title

Purification and iodinating activity of hog thyroid peroxidase.

Journal

J Biol Chem 242:5510-23 (1967)

Reference

4 [PMID:7021557]

Authors

Gavaret JM, Cahnmann HJ, Nunez J

Title

Thyroid hormone synthesis in thyroglobulin. The mechanism of the coupling reaction.

Journal

J Biol Chem 256:9167-73 (1981)

Reference

5 [PMID:7142155]

Authors

Ohtaki S, Nakagawa H, Nakamura M, Yamazaki I

Title

One- and two-electron oxidations of tyrosine, monoiodotyrosine, and diiodotyrosine catalyzed by hog thyroid peroxidase.

Journal

J Biol Chem 257:13398-403 (1982)

Reference

6 [PMID:6706930]

Authors

Magnusson RP, Taurog A, Dorris ML

Title

Mechanism of iodide-dependent catalatic activity of thyroid peroxidase and lactoperoxidase.

Journal

J Biol Chem 259:197-205 (1984)

Reference

7 [PMID:2996435]

Authors

Virion A, Courtin F, Deme D, Michot JL, Kaniewski J, Pommier J

Title

Spectral characteristics and catalytic properties of thyroid peroxidase-H2O2 compounds in the iodination and coupling reactions.

Journal

Arch Biochem Biophys 242:41-7 (1985)
DOI:10.1016/0003-9861(85)90477-1

Reference

8 [PMID:1497352]

Authors

Rawitch AB, Pollock G, Yang SX, Taurog A

Title

Thyroid peroxidase glycosylation: the location and nature of the N-linked oligosaccharide units in porcine thyroid peroxidase.

Journal

Arch Biochem Biophys 297:321-7 (1992)
DOI:10.1016/0003-9861(92)90679-Q

Sequence

[ssc:445522]

Reference

9 [PMID:8448141]

Authors

Sun W, Dunford HB

Title

Kinetics and mechanism of the peroxidase-catalyzed iodination of tyrosine.

Journal

Biochemistry 32:1324-31 (1993)
DOI:10.1021/bi00056a018

Reference

10 [PMID:8651700]

Authors

Taurog A, Dorris ML, Doerge DR

Title

Mechanism of simultaneous iodination and coupling catalyzed by thyroid peroxidase.

Journal

Arch Biochem Biophys 330:24-32 (1996)
DOI:10.1006/abbi.1996.0222

Reference

11 [PMID:16098474]

Authors

Ruf J, Carayon P

Title

Structural and functional aspects of thyroid peroxidase.

Journal

Arch Biochem Biophys 445:269-77 (2006)
DOI:10.1016/j.abb.2005.06.023

Other DBs

ExplorEnz - The Enzyme Database:

1.11.1.8

IUBMB Enzyme Nomenclature:

1.11.1.8

ExPASy - ENZYME nomenclature database:

1.11.1.8

BRENDA, the Enzyme Database:

1.11.1.8

CAS:

9031-28-1

LinkDB