| Entry |
D00322 Drug
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| Name |
Fluconazole (JP18/USP/INN);
Diflucan (TN) |
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| Product |
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| Generic |
FLUCONAZOLE (A-S Medication Solutions), FLUCONAZOLE (A-S Medication Solutions), FLUCONAZOLE (A-S Medication Solutions), FLUCONAZOLE (A-S Medication Solutions), FLUCONAZOLE (A-S Medication Solutions), FLUCONAZOLE (A-S Medication Solutions), FLUCONAZOLE (A-S Medication Solutions), FLUCONAZOLE (ANI Pharmaceuticals), FLUCONAZOLE (American Health Packaging), FLUCONAZOLE (Asclemed USA), FLUCONAZOLE (Asclemed USA), FLUCONAZOLE (Aurobindo Pharma Limited), FLUCONAZOLE (Aurobindo Pharma Limited), FLUCONAZOLE (AvPAK), FLUCONAZOLE (Baxter Healthcare Corporation), FLUCONAZOLE (BluePoint Laboratories), FLUCONAZOLE (Bryant Ranch Prepack), FLUCONAZOLE (Bryant Ranch Prepack), FLUCONAZOLE (Bryant Ranch Prepack), FLUCONAZOLE (Bryant Ranch Prepack), FLUCONAZOLE (Bryant Ranch Prepack), FLUCONAZOLE (Bryant Ranch Prepack), FLUCONAZOLE (Bryant Ranch Prepack), FLUCONAZOLE (Bryant Ranch Prepack), FLUCONAZOLE (Bryant Ranch Prepack), FLUCONAZOLE (Bryant Ranch Prepack), FLUCONAZOLE (Bryant Ranch Prepack), FLUCONAZOLE (Cardinal Health 107), FLUCONAZOLE (Chartwell RX), FLUCONAZOLE (Direct Rx), FLUCONAZOLE (Direct Rx), FLUCONAZOLE (Direct_Rx), FLUCONAZOLE (Dr. Reddy's Laboratories Limited), FLUCONAZOLE (Drug Ocean LLC), FLUCONAZOLE (Glenmark Pharmaceuticals), FLUCONAZOLE (Golden State Medical Supply), FLUCONAZOLE (Greenstone LLC), FLUCONAZOLE (Hainan Poly Pharm.), FLUCONAZOLE (Hikma Pharmaceuticals USA), FLUCONAZOLE (Hospira), FLUCONAZOLE (Major Pharmaceuticals), FLUCONAZOLE (McKesson Corporation DBA SKY Packaging), FLUCONAZOLE (NorthStar Rx LLC), FLUCONAZOLE (NorthStar Rx LLC), FLUCONAZOLE (Northwind Pharmaceuticals), FLUCONAZOLE (Northwind Pharmaceuticals), FLUCONAZOLE (Northwind Pharmaceuticals), FLUCONAZOLE (NuCare Pharmaceuticals), FLUCONAZOLE (NuCare Pharmaceuticals), FLUCONAZOLE (NuCare Pharmaceuticals), FLUCONAZOLE (NuCare Pharmaceuticals), FLUCONAZOLE (NuCare Pharmaceuticals), FLUCONAZOLE (NuCare Pharmaceuticals), FLUCONAZOLE (NuCare Pharmaceuticals), FLUCONAZOLE (NuCare Pharmaceuticals), FLUCONAZOLE (PD-Rx Pharmaceuticals), FLUCONAZOLE (PD-Rx Pharmaceuticals), FLUCONAZOLE (PD-Rx Pharmaceuticals), FLUCONAZOLE (PD-Rx Pharmaceuticals), FLUCONAZOLE (Pharmasource Meds), FLUCONAZOLE (Preferred Pharmaceuticals), FLUCONAZOLE (Preferred Pharmaceuticals), FLUCONAZOLE (Preferred Pharmaceuticals), FLUCONAZOLE (Preferred Pharmaceuticals), FLUCONAZOLE (Proficient Rx LP), FLUCONAZOLE (Proficient Rx LP), FLUCONAZOLE (Proficient Rx LP), FLUCONAZOLE (Proficient Rx LP), FLUCONAZOLE (Proficient Rx LP), FLUCONAZOLE (Proficient Rx LP), FLUCONAZOLE (Proficient Rx LP), FLUCONAZOLE (Proficient Rx LP), FLUCONAZOLE (Proficient Rx LP), FLUCONAZOLE (Proficient Rx LP), FLUCONAZOLE (Proficient Rx LP), FLUCONAZOLE (Proficient Rx LP), FLUCONAZOLE (Proficient Rx LP), FLUCONAZOLE (Proficient Rx LP), FLUCONAZOLE (Quality Care Products), FLUCONAZOLE (REMEDYREPACK), FLUCONAZOLE (REMEDYREPACK), FLUCONAZOLE (REMEDYREPACK), FLUCONAZOLE (REMEDYREPACK), FLUCONAZOLE (REMEDYREPACK), FLUCONAZOLE (REMEDYREPACK), FLUCONAZOLE (REMEDYREPACK), FLUCONAZOLE (REMEDYREPACK), FLUCONAZOLE (REMEDYREPACK), FLUCONAZOLE (REMEDYREPACK), FLUCONAZOLE (RedPharm Drug), FLUCONAZOLE (RedPharm Drug), FLUCONAZOLE (RedPharm Drug), FLUCONAZOLE (RedPharm Drug), FLUCONAZOLE (Redpharm Drug), FLUCONAZOLE (Redpharm Drug), FLUCONAZOLE (Rising Pharma Holdings), FLUCONAZOLE (Rising Pharma Holdings), FLUCONAZOLE (ST. MARY'S MEDICAL PARK PHARMACY), FLUCONAZOLE (Sagent Pharmaceuticals), FLUCONAZOLE (Sagent Pharmaceuticals), FLUCONAZOLE (Slate Run Pharmaceuticals), FLUCONAZOLE (St. Mary's Medical Park Pharmacy), FLUCONAZOLE (Taro Pharmaceuticals U.S.A.), FLUCONAZOLE (Zydus Lifesciences Limited), FLUCONAZOLE (Zydus Pharmaceuticals (USA)), FLUCONAZOLE (direct rx), FLUCONAZOLE IN SODIUM CHLORIDE (Hospira) |
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| Formula |
C13H12F2N6O
|
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| Exact mass |
306.1041
|
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| Mol weight |
306.27
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| Structure |
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| Simcomp |
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| Class |
Antifungal
DG01523 Triazole antifungal
Metabolizing enzyme inhibitor
DG01643 CYP2C9 inhibitor
DG01933 CYP2C19 inhibitor
DG02852 CYP3A/CYP3A4 inhibitor
DG01522 CYP3A4 inhibitor
|
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| Remark |
| Therapeutic category: | 6290 |
| Product (DG00371): | D00322<JP/US> D01429<JP> |
|
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| Efficacy |
Antifungal, Ergosterol biosynthesis inhibitor |
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| Disease |
Candidiasis [DS:H00363]
Cryptococcal meningitis [DS:H00364] |
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| Comment |
Triazole derivative
|
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| Target |
sterol 14alpha-demethylase [KO:K05917] |
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| Pathway |
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| Interaction |
CYP inhibition: CYP2C19 [HSA:1557], CYP2C9 [HSA:1559], CYP3A4 [HSA:1576]
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| Structure map |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
D DERMATOLOGICALS
D01 ANTIFUNGALS FOR DERMATOLOGICAL USE
D01A ANTIFUNGALS FOR TOPICAL USE
D01AC Imidazole and triazole derivatives
D01AC15 Fluconazole
D00322 Fluconazole (JP18/USP/INN) <JP/US>
J ANTIINFECTIVES FOR SYSTEMIC USE
J02 ANTIMYCOTICS FOR SYSTEMIC USE
J02A ANTIMYCOTICS FOR SYSTEMIC USE
J02AC Triazole and tetrazole derivatives
J02AC01 Fluconazole
D00322 Fluconazole (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Antifungals
Fluconazole
D00322 Fluconazole (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
6 Agents against pathologic organisms and parasites
62 Chemotherapeutics
629 Miscellaneous
6290 Miscellaneous
D00322 Fluconazole (JP18/USP/INN)
Drug groups [BR:br08330]
Antifungal
DG01523 Triazole antifungal
DG00371 Fluconazole
D00322 Fluconazole
Metabolizing enzyme inhibitor
DG01643 CYP2C9 inhibitor
DG00371 Fluconazole
D00322 Fluconazole
DG01933 CYP2C19 inhibitor
DG00371 Fluconazole
D00322 Fluconazole
DG02852 CYP3A/CYP3A4 inhibitor
DG01522 CYP3A4 inhibitor
DG00371 Fluconazole
D00322 Fluconazole
Drug classes [BR:br08332]
Antifungal
DG01523 Triazole antifungal
D00322 Fluconazole
Antimicrobials [BR:br08307]
Antifungals
Ergosterol biosynthesis inhibitor
Triazole
D00322 Fluconazole (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00322 Fluconazole
D00322 Fluconazole capsules
D00322 Fluconazole injection
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00322
Prodrugs [br08324.html]
D00322
Drug groups [BR:br08330]
Antifungal
DG01523 Triazole antifungal
DG00371 Fluconazole
Metabolizing enzyme inhibitor
DG01643 CYP2C9 inhibitor
DG00371 Fluconazole
DG01933 CYP2C19 inhibitor
DG00371 Fluconazole
DG02852 CYP3A/CYP3A4 inhibitor
DG01522 CYP3A4 inhibitor
DG00371 Fluconazole
Antimicrobials abbreviations [BR:br08327]
Antifungals
Ergosterol biosynthesis inhibitor
Triazole
DG00371 Fluconazole
Prodrugs [br08324.html]
DG00371
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 22
1 C8y C 22.8550 -18.0489
2 C1d C 22.8550 -20.3687
3 C8y C 24.0266 -17.3670
4 C8x C 21.6718 -17.3670
5 C1b C 21.6777 -21.0508
6 C1b C 24.0325 -21.0508
7 O1a O 22.8550 -21.7269
8 C8x C 24.0266 -16.0088
9 X F 25.2099 -18.0489
10 C8x C 21.6718 -16.0088
11 N4y N 20.4945 -20.3687
12 N4y N 25.2158 -20.3630
13 C8y C 22.8550 -15.3269
14 C8x C 20.3604 -19.0164
15 N5x N 19.2646 -20.9225
16 C8x C 25.3439 -19.0224
17 N5x N 26.4457 -20.9225
18 X F 22.8550 -13.9630
19 N5x N 19.0315 -18.7367
20 C8x C 18.3494 -19.9199
21 N5x N 26.6730 -18.7309
22 C8x C 27.3607 -19.9142
BOND 24
1 1 2 1
2 1 3 2
3 1 4 1
4 2 5 1
5 2 6 1
6 2 7 1
7 3 8 1
8 3 9 1
9 4 10 2
10 5 11 1
11 6 12 1
12 8 13 2
13 11 14 1
14 11 15 1
15 12 16 1
16 12 17 1
17 13 18 1
18 14 19 2
19 15 20 2
20 16 21 2
21 17 22 2
22 10 13 1
23 19 20 1
24 21 22 1
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