| Entry |
D00926 Drug
|
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| Name |
Vancomycin hydrochloride (JP18/USP);
Vancoled (TN);
Vancocin (TN) |
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| Product |
|
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| Generic |
VANCOMYCIN (Sagent Pharmaceuticals), VANCOMYCIN HYDROCHLORIDE (ANI Pharmaceuticals), VANCOMYCIN HYDROCHLORIDE (ANI Pharmaceuticals), VANCOMYCIN HYDROCHLORIDE (Amneal Pharmaceuticals NY LLC), VANCOMYCIN HYDROCHLORIDE (Ascend Laboratories), VANCOMYCIN HYDROCHLORIDE (BluePoint Laboratories), VANCOMYCIN HYDROCHLORIDE (Bryant Ranch Prepack), VANCOMYCIN HYDROCHLORIDE (Bryant Ranch Prepack), VANCOMYCIN HYDROCHLORIDE (Bryant Ranch Prepack), VANCOMYCIN HYDROCHLORIDE (Bryant Ranch Prepack), VANCOMYCIN HYDROCHLORIDE (Bryant Ranch Prepack), VANCOMYCIN HYDROCHLORIDE (Bryant Ranch Prepack), VANCOMYCIN HYDROCHLORIDE (Camber Pharmaceuticals), VANCOMYCIN HYDROCHLORIDE (Cameron Pharmaceuticals), VANCOMYCIN HYDROCHLORIDE (Civica), VANCOMYCIN HYDROCHLORIDE (Civica), VANCOMYCIN HYDROCHLORIDE (Eugia US LLC), VANCOMYCIN HYDROCHLORIDE (Eugia US LLC), VANCOMYCIN HYDROCHLORIDE (Eugia US LLC), VANCOMYCIN HYDROCHLORIDE (Fresenius Kabi USA), VANCOMYCIN HYDROCHLORIDE (Fresenius Kabi USA), VANCOMYCIN HYDROCHLORIDE (Fresenius Kabi USA), VANCOMYCIN HYDROCHLORIDE (Fresenius Kabi USA), VANCOMYCIN HYDROCHLORIDE (Fresenius Kabi USA), VANCOMYCIN HYDROCHLORIDE (Fresenius Kabi USA), VANCOMYCIN HYDROCHLORIDE (Fresenius Kabi), VANCOMYCIN HYDROCHLORIDE (Fresenius Kabi), VANCOMYCIN HYDROCHLORIDE (Fresenius Kabi), VANCOMYCIN HYDROCHLORIDE (Gland Pharma Limited), VANCOMYCIN HYDROCHLORIDE (Gland Pharma Limited), VANCOMYCIN HYDROCHLORIDE (Henry Schein), VANCOMYCIN HYDROCHLORIDE (Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals), VANCOMYCIN HYDROCHLORIDE (Hikma Pharmaceuticals USA), VANCOMYCIN HYDROCHLORIDE (Hikma Pharmaceuticals USA), VANCOMYCIN HYDROCHLORIDE (Hikma Pharmaceuticals USA), VANCOMYCIN HYDROCHLORIDE (Hikma Pharmaceuticals USA), VANCOMYCIN HYDROCHLORIDE (Hospira), VANCOMYCIN HYDROCHLORIDE (Hospira), VANCOMYCIN HYDROCHLORIDE (Hospira), VANCOMYCIN HYDROCHLORIDE (Hospira), VANCOMYCIN HYDROCHLORIDE (Hospira), VANCOMYCIN HYDROCHLORIDE (Lupin Pharmaceuticals), VANCOMYCIN HYDROCHLORIDE (Meitheal Pharmaceuticals), VANCOMYCIN HYDROCHLORIDE (Meitheal Pharmaceuticals), VANCOMYCIN HYDROCHLORIDE (Meitheal Pharmaceuticals), VANCOMYCIN HYDROCHLORIDE (Mylan Institutional LLC), VANCOMYCIN HYDROCHLORIDE (Mylan Institutional LLC), VANCOMYCIN HYDROCHLORIDE (Mylan Institutional LLC), VANCOMYCIN HYDROCHLORIDE (NorthStar Rx LLC), VANCOMYCIN HYDROCHLORIDE (NorthStar Rx LLC), VANCOMYCIN HYDROCHLORIDE (PAI Holdings), VANCOMYCIN HYDROCHLORIDE (PAI Holdings), VANCOMYCIN HYDROCHLORIDE (SAMSON MEDICAL TECHNOLOGIES LLC), VANCOMYCIN HYDROCHLORIDE (Sagent Pharmaceuticals), VANCOMYCIN HYDROCHLORIDE (Slate Run Pharmaceuticals), VANCOMYCIN HYDROCHLORIDE (Slate Run Pharmaceuticals), VANCOMYCIN HYDROCHLORIDE (Xellia Pharmaceuticals USA LLC), VANCOMYCIN HYDROCHLORIDE (Xellia Pharmaceuticals USA LLC), VANCOMYCIN HYDROCHLORIDE (Xellia Pharmaceuticals USA LLC), VANCOMYCIN HYDROCHLORIDE FOR ORAL SOLUTION (Wilshire Pharmaceuticals) |
|---|
| Formula |
C66H75Cl2N9O24. HCl
|
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| Exact mass |
1483.4069
|
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| Mol weight |
1485.71
|
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| Structure |
|
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| Simcomp |
|
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| Class |
Antibacterial
DG01580 Glycopeptide antibiotic
|
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| Remark |
| Therapeutic category: | 6113 |
| Product (DG00086): | D00926<JP/US> |
|
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| Efficacy |
Antibacterial, Cell wall biosynthesis inhibitor |
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| Disease |
Infections caused by methicillin-resistant staphylococci [DS:H00330]
Staphylococcal infection [DS:H01175]
Endocarditis caused by enterococci [DS:H00334] |
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| Comment |
Vancomycin makes complex formation with D-alanyl-D-alanine of Peptidoglycan, and inhibites cross-link between protein and peptideglycan.
Glycopeptide
|
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| Target |
peptidoglycan (D-Ala-D-Ala) |
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| Pathway |
|
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| Interaction |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
A07A INTESTINAL ANTIINFECTIVES
A07AA Antibiotics
A07AA09 Vancomycin
D00926 Vancomycin hydrochloride (JP18/USP) <JP/US>
J ANTIINFECTIVES FOR SYSTEMIC USE
J01 ANTIBACTERIALS FOR SYSTEMIC USE
J01X OTHER ANTIBACTERIALS
J01XA Glycopeptide antibacterials
J01XA01 Vancomycin
D00926 Vancomycin hydrochloride (JP18/USP) <JP/US>
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01A ANTIINFECTIVES
S01AA Antibiotics
S01AA28 Vancomycin
D00926 Vancomycin hydrochloride (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
Antibacterials
Antibacterials, Other
Vancomycin
D00926 Vancomycin hydrochloride (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
6 Agents against pathologic organisms and parasites
61 Antibiotics
611 Acting mainly on gram-positive bacteria
6113 Vancomycins
D00926 Vancomycin hydrochloride (JP18/USP)
Drug groups [BR:br08330]
Antibacterial
DG01580 Glycopeptide antibiotic
DG00086 Vancomycin
D00926 Vancomycin hydrochloride
Drug classes [BR:br08332]
Antibacterial
DG01580 Glycopeptide antibiotic
D00926 Vancomycin hydrochloride
Antimicrobials [BR:br08307]
Antibacterials
Cell wall biosynthesis inhibitor, other
Glycopeptide
D00926 Vancomycin hydrochloride (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00926 Vancomycin hydrochloride
D00926 Vancomycin hydrochloride for injection
Drug groups [BR:br08330]
Antibacterial
DG01580 Glycopeptide antibiotic
DG00086 Vancomycin
Antimicrobials abbreviations [BR:br08327]
Antibacterials
Cell wall biosynthesis inhibitor, other
Glycopeptide
DG00086 Vancomycin
|
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 102
1 X Cl 50.3279 -23.5014
2 C1y C 39.5722 -29.5878
3 C1x C 39.5115 -28.2456
4 O2x O 40.7243 -30.2558
5 C1z C 40.7427 -27.5938
6 C1y C 41.8857 -29.6039
7 C1y C 41.8949 -28.2617
8 C1a C 39.8150 -26.5077
9 N1a N 41.7058 -26.5208
10 C1a C 43.0453 -30.2719
11 O1a O 43.0637 -27.6100
12 C8y C 37.3497 -25.3159
13 C8y C 38.5062 -24.6485
14 C8y C 36.1926 -24.6558
15 O2a O 37.3580 -26.6508
16 C8x C 38.4989 -23.3064
17 O2x O 39.6557 -25.3086
18 C8x C 36.1853 -23.3212
19 O2x O 35.0286 -25.3086
20 C1y C 36.1979 -28.4156
21 C8y C 37.3348 -22.6391
22 C8y C 40.8199 -24.6411
23 C8y C 33.8643 -24.6485
24 C1y C 36.1979 -29.7576
25 O2x O 35.0339 -27.7483
26 C1y C 37.2975 -20.5243
27 C8y C 40.8199 -23.3064
28 C8x C 41.9767 -25.3011
29 C8y C 32.7076 -25.3086
30 C8x C 33.8569 -23.3064
31 C1y C 35.0486 -30.4401
32 C1y C 33.8696 -28.4304
33 C5x C 38.4469 -19.8494
34 N1x N 36.1483 -19.8567
35 C8x C 41.9767 -22.6315
36 X Cl 39.6557 -22.6242
37 C8x C 43.1261 -24.6411
38 C8x C 31.5506 -24.6558
39 X Cl 32.7000 -26.6435
40 C8x C 32.6927 -22.6391
41 C1y C 33.8768 -29.7800
42 O1a O 35.0412 -31.7673
43 N1x N 39.6112 -20.5243
44 O5x O 38.4396 -18.5147
45 C5x C 34.9913 -20.5316
46 C8y C 43.1261 -23.3064
47 C8y C 31.5434 -23.3212
48 O1a O 32.7126 -30.4326
49 C1y C 40.8305 -19.8494
50 C1y C 33.8347 -19.8643
51 O5x O 34.9841 -21.8664
52 C1y C 44.2755 -22.6242
53 C1y C 30.3790 -22.6391
54 C8y C 40.7679 -18.5147
55 C5x C 41.9174 -20.5167
56 N1x N 32.6778 -20.5392
57 C1y C 44.2680 -20.5243
58 O1a O 45.4323 -23.2991
59 C1y C 30.3716 -20.5465
60 O1a O 29.2149 -23.3064
61 C8x C 41.9249 -17.8472
62 C8x C 39.6039 -17.8472
63 N1x N 43.0740 -19.8419
64 C5x C 31.5285 -19.8716
65 C5x C 45.4250 -19.8494
66 N1b N 29.2075 -19.8791
67 C8y C 41.9249 -16.5051
68 C8x C 39.6039 -16.5124
69 O5x O 31.5909 -18.5369
70 N1x N 45.4175 -18.5147
71 O5x O 46.5816 -20.5243
72 C5a C 28.0507 -20.5392
73 C8y C 43.0889 -15.8524
74 C8y C 40.7605 -15.8375
75 C1y C 44.2531 -17.8472
76 C1c C 26.8938 -19.8716
77 O5a O 28.0433 -21.8737
78 C8y C 44.2458 -16.5124
79 C8y C 43.0816 -14.5104
80 C6a C 46.4927 -16.5644
81 C1b C 26.8865 -18.5369
82 N1b N 25.7296 -20.5316
83 C8x C 45.4026 -15.8375
84 C8x C 44.2310 -13.8355
85 O1a O 41.9174 -13.8355
86 C8y C 45.3953 -14.4955
87 O1a O 46.5445 -13.8134
88 O5x O 41.9208 -21.8830
89 O1a O 40.7552 -14.4429
90 O6a O 47.6827 -17.2570
91 O6a O 46.4972 -15.2008
92 C1a C 25.7267 -21.8829
93 C1c C 25.7012 -17.8621
94 C1a C 24.4841 -18.5745
95 C1a C 25.6926 -16.5097
96 C1b C 33.8310 -17.6810
97 C5a C 35.0048 -16.9989
98 N1a N 36.1772 -17.6715
99 O5a O 35.0011 -15.6143
100 C1b C 32.6764 -27.7509
101 O1a O 31.5141 -28.4312
102 O2a O 37.8151 -30.4432
BOND 110
1 2 3 1
2 2 4 1
3 3 5 1
4 4 6 1
5 5 7 1
6 5 8 1 #Up
7 5 9 1 #Down
8 6 10 1 #Down
9 7 11 1 #Down
10 6 7 1
11 12 13 1
12 12 14 2
13 12 15 1
14 13 16 2
15 13 17 1
16 14 18 1
17 14 19 1
18 20 15 1 #Up
19 16 21 1
20 17 22 1
21 19 23 1
22 20 24 1
23 20 25 1
24 21 26 1
25 22 27 1
26 22 28 2
27 23 29 1
28 23 30 2
29 24 31 1
30 25 32 1
31 26 33 1
32 26 34 1 #Up
33 27 35 2
34 27 36 1
35 28 37 1
36 29 38 2
37 29 39 1
38 30 40 1
39 31 41 1
40 31 42 1 #Up
41 33 43 1
42 33 44 2
43 34 45 1
44 35 46 1
45 38 47 1
46 41 48 1 #Down
47 43 49 1
48 45 50 1
49 45 51 2
50 46 52 1
51 47 53 1
52 49 54 1
53 49 55 1 #Down
54 50 56 1
55 52 57 1
56 52 58 1 #Down
57 53 59 1
58 53 60 1 #Up
59 54 61 1
60 54 62 2
61 55 63 1
62 56 64 1
63 57 65 1
64 59 66 1 #Up
65 61 67 2
66 62 68 1
67 64 69 2
68 65 70 1
69 65 71 2
70 66 72 1
71 67 73 1
72 67 74 1
73 70 75 1
74 72 76 1
75 72 77 2
76 73 78 2
77 73 79 1
78 75 80 1 #Down
79 76 81 1
80 76 82 1 #Down
81 78 83 1
82 79 84 2
83 79 85 1
84 83 86 2
85 86 87 1
86 18 21 2
87 32 41 1
88 37 46 2
89 40 47 2
90 57 63 1 #Down
91 59 64 1 #Down
92 68 74 2
93 75 78 1
94 84 86 1
95 55 88 2
96 74 89 1
97 80 90 1
98 80 91 2
99 82 92 1
100 81 93 1
101 93 94 1
102 93 95 1
103 50 96 1 #Up
104 96 97 1
105 97 98 1
106 97 99 2
107 32 100 1 #Up
108 100 101 1
109 24 102 1 #Down
110 2 102 1 #Up
|
|---|
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