| Entry |
D01358 Drug
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| Name |
Mianserin hydrochloride (JAN/USAN);
Tetramide (TN) |
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| Formula |
C18H20N2. HCl
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| Exact mass |
300.1393
|
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| Mol weight |
300.82
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| Structure |
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| Simcomp |
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| Class |
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01465 alpha-Adrenergic receptor antagonist
DG01460 alpha2-Adrenergic receptor antagonist
Neuropsychiatric agent
DG01729 Tetracyclic antidepressant
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG01644 CYP2D6 substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
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| Remark |
| Therapeutic category: | 1179 |
| Product (DG00951): | D01358<JP> |
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| Efficacy |
Antidepressant |
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| Comment |
Tetracyclic antidepressants
Antihistaminic
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| Target |
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
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| Metabolism |
Enzyme: CYP3A4 [HSA:1576], CYP1A2 [HSA:1544], CYP2D6 [HSA:1565]
|
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| Interaction |
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| Structure map |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N06 PSYCHOANALEPTICS
N06A ANTIDEPRESSANTS
N06AX Other antidepressants
N06AX03 Mianserin
D01358 Mianserin hydrochloride (JAN/USAN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
117 Psychotropics
1179 Others
D01358 Mianserin hydrochloride (JAN/USAN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01465 alpha-Adrenergic receptor antagonist
DG01460 alpha2-Adrenergic receptor antagonist
DG00951 Mianserin
D01358 Mianserin hydrochloride
Neuropsychiatric agent
DG01729 Tetracyclic antidepressant
DG00951 Mianserin
D01358 Mianserin hydrochloride
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG00951 Mianserin
D01358 Mianserin hydrochloride
DG01644 CYP2D6 substrate
DG00951 Mianserin
D01358 Mianserin hydrochloride
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00951 Mianserin
D01358 Mianserin hydrochloride
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Adrenaline
ADRA2
D01358 Mianserin hydrochloride (JAN/USAN) <JP>
Histamine
HRH1
D01358 Mianserin hydrochloride (JAN/USAN) <JP>
Serotonin
HTR2A
D01358 Mianserin hydrochloride (JAN/USAN) <JP>
HTR2C
D01358 Mianserin hydrochloride (JAN/USAN) <JP>
Ion channels
Ligand-gated ion channels
Serotonin
HTR3
D01358 Mianserin hydrochloride (JAN/USAN) <JP>
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D01358
Drug groups [BR:br08330]
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01465 alpha-Adrenergic receptor antagonist
DG01460 alpha2-Adrenergic receptor antagonist
DG00951 Mianserin
Neuropsychiatric agent
DG01729 Tetracyclic antidepressant
DG00951 Mianserin
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG00951 Mianserin
DG01644 CYP2D6 substrate
DG00951 Mianserin
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00951 Mianserin
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 21
1 X Cl 21.7700 -20.6500
2 C8y C 19.4600 -15.8900
3 N1y N 18.5500 -16.9400
4 C1y C 17.1500 -16.9400
5 C8y C 16.3100 -15.8200
6 C8y C 19.1800 -14.4900
7 C8y C 16.6600 -14.4900
8 C1x C 17.9200 -13.8600
9 C8x C 15.6800 -13.5100
10 C8x C 14.2800 -13.9300
11 C8x C 14.0000 -15.2600
12 C8x C 14.9800 -16.2400
13 C8x C 20.7900 -16.3100
14 C8x C 21.8400 -15.4000
15 C8x C 21.5600 -14.0000
16 C8x C 20.2300 -13.5800
17 C1x C 16.4500 -18.1300
18 N1y N 17.1500 -19.3900
19 C1x C 18.5500 -19.3900
20 C1x C 19.2500 -18.2000
21 C1a C 16.4500 -20.5800
BOND 23
1 4 5 1
2 2 6 1
3 5 7 1
4 3 4 1
5 6 8 1
6 2 3 1
7 7 8 1
8 7 9 2
9 9 10 1
10 10 11 2
11 11 12 1
12 5 12 2
13 2 13 2
14 13 14 1
15 14 15 2
16 15 16 1
17 6 16 2
18 4 17 1
19 17 18 1
20 18 19 1
21 19 20 1
22 3 20 1
23 18 21 1
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