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KEGG DRUG: Metaraminol

Entry

D08192 Drug

Name

Metaraminol (INN)

Formula

C9H13NO2

Exact mass

167.0946

Mol weight

167.20

Structure

Simcomp

Class

Cardiovascular agent
DG01703  Cardiotonic
  DG01702  Phenethylamine cardiotonic
DG01456  Adrenergic receptor agonist
  DG01450  alpha-Adrenergic receptor agonist

Remark

Same as:

C07146

ATC code:

C01CA09

Chemical structure group:

DG00218

Efficacy

Antihypotensive, alpha-Adrenergic receptor agonist

Comment

Phenethylamine derivative

Target

ADRA1 [HSA:148 147 146] [KO:K04135 K04136 K04137]
ADRA2 [HSA:150 151 152] [KO:K04138 K04139 K04140]

Pathway

hsa04020

Calcium signaling pathway

hsa04080

Neuroactive ligand-receptor interaction

hsa04261

Adrenergic signaling in cardiomyocytes

hsa04270

Vascular smooth muscle contraction

Interaction

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01C CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES
    C01CA Adrenergic and dopaminergic agents
     C01CA09 Metaraminol
      D08192  Metaraminol (INN)
Drug groups [BR:br08330]
Cardiovascular agent
  DG01703  Cardiotonic
   DG01702  Phenethylamine cardiotonic
    DG00218  Metaraminol
     D08192  Metaraminol
  DG01456  Adrenergic receptor agonist
   DG01450  alpha-Adrenergic receptor agonist
    DG00218  Metaraminol
     D08192  Metaraminol
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRA1
     D08192  Metaraminol (INN)
    ADRA2
     D08192  Metaraminol (INN)
Drug groups [BR:br08330]
Cardiovascular agent
  DG01703  Cardiotonic
   DG01702  Phenethylamine cardiotonic
    DG00218  Metaraminol
  DG01456  Adrenergic receptor agonist
   DG01450  alpha-Adrenergic receptor agonist
    DG00218  Metaraminol

Other DBs

CAS:

54-49-9

PubChem:

ChEBI:

LigandBox:

NIKKAJI:

LinkDB

KCF data

ATOM        12
            1   C8y C     8.1200  -18.6900
            2   C8x C     8.1200  -20.0900
            3   C8x C     9.3324  -20.7900
            4   C8x C    10.5449  -20.0900
            5   C8y C    10.5449  -18.6900
            6   C8x C     9.3324  -17.9900
            7   O1a O     6.9076  -17.9900
            8   C1c C    11.7760  -17.9790
            9   C1c C    12.9812  -18.6747
            10  O1a O    11.7757  -16.5901
            11  N1a N    14.1635  -17.9919
            12  C1a C    12.9816  -20.0896
BOND        12
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     1   7 1
            8     5   8 1
            9     8   9 1
            10    8  10 1 #Up
            11    9  11 1 #Up
            12    9  12 1