kegg.jp

KEGG DRUG: Mianserin

Entry

D08216 Drug

Name

Mianserin (INN);
Tolvon (TN)

Formula

C18H20N2

Exact mass

264.1626

Mol weight

264.36

Structure

Simcomp

Class

Cardiovascular agent
DG01466  Adrenergic receptor antagonist
  DG01465  alpha-Adrenergic receptor antagonist
   DG01460  alpha2-Adrenergic receptor antagonist
Neuropsychiatric agent
DG01729  Tetracyclic antidepressant
DG03077  Noradrenergic and specific serotonergic antidepressant (NaSSA)
Metabolizing enzyme substrate
DG01892  CYP1A2 substrate
DG01644  CYP2D6 substrate
DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate

Remark

ATC code:

N06AX03

Chemical structure group:

DG00951

Product (DG00951):

D01358<JP>

Efficacy

Antidepressant

Comment

tetracyclic antidepressants

Target

ADRA2 [HSA:150 151 152] [KO:K04138 K04139 K04140]
HTR2A [HSA:3356] [KO:K04157]
HTR2C [HSA:3358] [KO:K04157]
HTR3 [HSA:3359 9177 170572 200909 285242] [KO:K04819]
HRH1 [HSA:3269] [KO:K04149]

Pathway

hsa04080

Neuroactive ligand-receptor interaction

hsa04726

Serotonergic synapse

Metabolism

Enzyme: CYP3A4 [HSA:1576], CYP1A2 [HSA:1544], CYP2D6 [HSA:1565]

Interaction

Structure map

map07027

Antidepressants

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AX Other antidepressants
     N06AX03 Mianserin
      D08216  Mianserin (INN)
Drug groups [BR:br08330]
Cardiovascular agent
  DG01466  Adrenergic receptor antagonist
   DG01465  alpha-Adrenergic receptor antagonist
    DG01460  alpha2-Adrenergic receptor antagonist
     DG00951  Mianserin
      D08216  Mianserin
Neuropsychiatric agent
  DG01729  Tetracyclic antidepressant
   DG00951  Mianserin
    D08216  Mianserin
  DG03077  Noradrenergic and specific serotonergic antidepressant (NaSSA)
   D08216  Mianserin
Metabolizing enzyme substrate
  DG01892  CYP1A2 substrate
   DG00951  Mianserin
    D08216  Mianserin
  DG01644  CYP2D6 substrate
   DG00951  Mianserin
    D08216  Mianserin
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00951  Mianserin
     D08216  Mianserin
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRA2
     D08216  Mianserin (INN)
   Histamine
    HRH1
     D08216  Mianserin (INN)
   Serotonin
    HTR2A
     D08216  Mianserin (INN)
    HTR2C
     D08216  Mianserin (INN)
Ion channels
  Ligand-gated ion channels
   Serotonin
    HTR3
     D08216  Mianserin (INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
  D08216
Drug groups [BR:br08330]
Cardiovascular agent
  DG01466  Adrenergic receptor antagonist
   DG01465  alpha-Adrenergic receptor antagonist
    DG01460  alpha2-Adrenergic receptor antagonist
     DG00951  Mianserin
Neuropsychiatric agent
  DG01729  Tetracyclic antidepressant
   DG00951  Mianserin
Metabolizing enzyme substrate
  DG01892  CYP1A2 substrate
   DG00951  Mianserin
  DG01644  CYP2D6 substrate
   DG00951  Mianserin
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00951  Mianserin

Other DBs

CAS:	24219-97-4

PubChem:

96024904

LigandBox:

D08216

NIKKAJI:

J16.389I

LinkDB

KCF data

ATOM        20
            1   C8y C    20.1600  -15.0500
            2   N1y N    19.2500  -16.1000
            3   C1y C    17.8500  -16.1000
            4   C8y C    17.0100  -14.9800
            5   C8y C    19.8800  -13.6500
            6   C8y C    17.3600  -13.6500
            7   C1x C    18.6200  -13.0200
            8   C8x C    16.3800  -12.6700
            9   C8x C    14.9800  -13.0900
            10  C8x C    14.7000  -14.4200
            11  C8x C    15.6800  -15.4000
            12  C8x C    21.4900  -15.4700
            13  C8x C    22.5400  -14.5600
            14  C8x C    22.2600  -13.1600
            15  C8x C    20.9300  -12.7400
            16  C1x C    17.1500  -17.2900
            17  N1y N    17.8500  -18.5500
            18  C1x C    19.2500  -18.5500
            19  C1x C    19.9500  -17.3600
            20  C1a C    17.1500  -19.7400
BOND        23
            1     3   4 1
            2     1   5 1
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     6   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    4  11 2
            13    1  12 2
            14   12  13 1
            15   13  14 2
            16   14  15 1
            17    5  15 2
            18    3  16 1
            19   16  17 1
            20   17  18 1
            21   18  19 1
            22    2  19 1
            23   17  20 1