Figure 1 | Scientific Reports
Human colon cancers display apoptotic cell death at the tumour/stroma interface. (A–C) HUGL-1 (A), YAP (B) and c-MYC/Cas3 (C) staining of an in situ carcinoma. The arrow in (A) highlights a region of residual HUGL-1 protein localisation. In (C), the arrows indicate the presence of Cas3-positive cells within the transforming epithelium, while the arrowheads point to apoptotic stromal cells. (D–I) HUGL-1 (D,G), YAP (E,H) and c-MYC/Cas3 (F,I) staining of invasive carcinomas. The arrowheads in I indicate some stromal cells undergoing apoptotic death. (J–O) HUGL-1 (J,M), YAP (K,N) and c-MYC/Cas3 (L,O) staining of metastatic cancers. The arrowheads in (L and O) indicate Cas-3 positive stromal cells. Scale bars are indicated in each frame.