ncbi.nlm.nih.gov

ADRA2C adrenoceptor alpha 2C [Homo sapiens (human)] - Gene - NCBI

Official Symbol
ADRA2Cprovided by HGNC
Official Full Name
adrenoceptor alpha 2Cprovided by HGNC
Primary source
HGNC:HGNC:283
See related
Ensembl:ENSG00000184160 MIM:104250; AllianceGenome:HGNC:283
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ADRA2L2; ADRARL2; ADRA2RL2; ALPHA2CAR
Summary
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences. [provided by RefSeq, Jul 2008]
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (3766385..3768526)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (3765283..3767445)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (3768112..3770253)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes

Related articles in PubMed

  1. Sympathoneural and adrenomedullary functional effects of alpha2C-adrenoreceptor gene polymorphism in healthy humans. Neumeister A, et al. Pharmacogenet Genomics, 2005 Mar. PMID 15861038
  2. The predicted N-terminal signal sequence of the human α₂C-adrenoceptor does not act as a functional cleavable signal peptide. Jahnsen JA, et al. Eur J Pharmacol, 2012 Jun 5. PMID 22503931
  3. The α(2C)-Del322-325 adrenoceptor polymorphism and the occurrence of left ventricular hypertrophy in hypertensives. Savva J, et al. Blood Press, 2012 Apr. PMID 22040172
  4. An in-frame deletion in the alpha(2C) adrenergic receptor is common in African--Americans. Feng J, et al. Mol Psychiatry, 2001 Mar. PMID 11317218
  5. Polymorphisms of cardiac presynaptic alpha2C adrenergic receptors: Diverse intragenic variability with haplotype-specific functional effects. Small KM, et al. Proc Natl Acad Sci U S A, 2004 Aug 31. PMID 15319474, Free PMC Article

See all (103) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

  1. Genetic biomarkers of life-threatening pheochromocytoma-induced cardiomyopathy.

    Title: Genetic biomarkers of life-threatening pheochromocytoma-induced cardiomyopathy.

  2. alpha2A- and alpha2C-adrenoceptor expression and functionality in postmortem prefrontal cortex of schizophrenia subjects.

    Title: α(2A)- and α(2C)-adrenoceptor expression and functionality in postmortem prefrontal cortex of schizophrenia subjects.

  3. Prognostic significance of alpha- and beta2-adrenoceptor gene expression in breast cancer patients.

    Title: Prognostic significance of α- and β2-adrenoceptor gene expression in breast cancer patients.

  4. High alpha2-Adrenergic Receptor expression is associated with Pathogenesis of Preeclampsia and Fetal Growth Restriction.

    Title: Human Placenta Expresses α(2)-Adrenergic Receptors and May Be Implicated in Pathogenesis of Preeclampsia and Fetal Growth Restriction.

  5. alpha2A- and alpha2C-adrenoceptors are functional receptors for norepinephrine, dopamine, and other previously assumed selective D2-like receptor ligands.

    Title: α(2A)- and α(2C)-Adrenoceptors as Potential Targets for Dopamine and Dopamine Receptor Ligands.

  6. The frequency of alpha2CDel322-325-AR in suicide and non-suicide victims was similar. Genotype frequencies for the alpha2CDel322-325-AR polymorphism in depressed and schizophrenic subjects were higher than in controls, but these differences did not reach statistical significance. The results indicate that alpha2CDel322-325-AR may play a role in the pathophysiology of opiate abuse and dependence.

    Title: Alpha2C-adrenoceptor Del322-325 polymorphism and risk of psychiatric disorders: significant association with opiate abuse and dependence.

  7. Immunoreactivity for ADRA2C was densely distributed in vascular smooth muscle of nasal turbinates.

    Title: Immunohistochemical localization of alpha and beta adrenergic receptors in the human nasal turbinate.

  8. ADRA2c is associated with heart rate recovery after exercise.

    Title: Genetic variation in alpha2-adrenoreceptors and heart rate recovery after exercise.

  9. Common polymorphisms in the ADRA2C gene are not associated with orthostatic hypotension risk in Chinese.

    Title: Association between Common Genetic Variants of α2A-, α2B-, and α2C-Adrenergic Receptors and Orthostatic Hypotension.

  10. Adrenergic receptor genotype influences heart failure severity and beta-blocker response in children with dilated cardiomyopathy.

    Title: Adrenergic receptor genotype influences heart failure severity and β-blocker response in children with dilated cardiomyopathy.

Products Interactant Other Gene Complex Source Pubs Description

Markers

Preferred Names
alpha-2C adrenergic receptor
Names
adrenergic, alpha-2C-, receptor
alpha-2 adrenergic receptor subtype C4
alpha-2C adrenoceptor
alpha-2C adrenoreceptor
alpha-2CAR
alpha2-AR-C4