ncbi.nlm.nih.gov

Igf2 insulin-like growth factor 2 [Mus musculus (house mouse)] - Gene - NCBI

Location:
7 F5; 7 87.99 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (142204505..142220566, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (142650768..142666816, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001122736.2 → NP_001116208.1  insulin-like growth factor 2 isoform 2 preproprotein

    See identical proteins and their annotated locations for NP_001116208.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate exon at its 5' terminus and uses a downstream in-frame start codon, compared to variant 1. This results in a protein (isoform 2) with a shorter N-terminus, compared to isoform 1. Variants 2 and 3 encode the same protein.
    Source sequence(s)
    AC013548, BC058615, CN527329
    Consensus CDS
    CCDS52458.1
    UniProtKB/Swiss-Prot
    E9QLW5, P09535
    Related
    ENSMUSP00000101556.2, ENSMUST00000105936.8
    Conserved Domains (2) summary
    cd04368
    Location:28 → 91
    IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
    pfam08365
    Location:112 → 166
    IGF2_C; Insulin-like growth factor II E-peptide

  2. NM_001122737.2 → NP_001116209.1  insulin-like growth factor 2 isoform 2 preproprotein

    See identical proteins and their annotated locations for NP_001116209.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate exon at its 5' terminus and uses a downstream in-frame start codon, compared to variant 1. This results in a protein (isoform 2) with a shorter N-terminus, compared to isoform 1. Variants 2, 3, 4 and 5 encode the same protein.
    Source sequence(s)
    AC013548, BC058615
    Consensus CDS
    CCDS52458.1
    UniProtKB/Swiss-Prot
    E9QLW5, P09535
    Related
    ENSMUSP00000000033.6, ENSMUST00000000033.12
    Conserved Domains (2) summary
    cd04368
    Location:28 → 91
    IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
    pfam08365
    Location:112 → 166
    IGF2_C; Insulin-like growth factor II E-peptide

  3. NM_001315488.1 → NP_001302417.1  insulin-like growth factor 2 isoform 2 preproprotein

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate exon at its 5' terminus and uses a downstream in-frame start codon, compared to variant 1. This results in a protein (isoform 2) with a shorter N-terminus, compared to isoform 1. Variants 2, 3, 4 and 5 encode the same protein.
    Source sequence(s)
    AC013548, CN666734
    Consensus CDS
    CCDS52458.1
    UniProtKB/Swiss-Prot
    E9QLW5, P09535
    Related
    ENSMUSP00000101555.2, ENSMUST00000105935.8
    Conserved Domains (2) summary
    cd04368
    Location:28 → 91
    IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
    pfam08365
    Location:112 → 166
    IGF2_C; Insulin-like growth factor II E-peptide

  4. NM_001315489.1 → NP_001302418.1  insulin-like growth factor 2 isoform 2 preproprotein

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate exon at its 5' terminus, lacks a portion of the 3' UTR and uses a downstream in-frame start codon, compared to variant 1. This results in a protein (isoform 2) with a shorter N-terminus, compared to isoform 1. Variants 2, 3, 4 and 5 encode the same protein.
    Source sequence(s)
    AC013548, BC053489
    Consensus CDS
    CCDS52458.1
    UniProtKB/Swiss-Prot
    E9QLW5, P09535
    Conserved Domains (2) summary
    cd04368
    Location:28 → 91
    IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
    pfam08365
    Location:112 → 166
    IGF2_C; Insulin-like growth factor II E-peptide

  5. NM_010514.3 → NP_034644.2  insulin-like growth factor 2 isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). This isoform (1) may undergo proteolytic processing similar to isoform 2.
    Source sequence(s)
    AC013548, CF742200
    Consensus CDS
    CCDS22033.2
    UniProtKB/Swiss-Prot
    P09535
    Related
    ENSMUSP00000114076.2, ENSMUST00000121128.8
    Conserved Domains (2) summary
    cd04368
    Location:39 → 102
    IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...
    pfam08365
    Location:123 → 177
    IGF2_C; Insulin-like growth factor II E-peptide

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    142204505..142220566 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152697.1 → XP_036008590.1  insulin-like growth factor II isoform X1

    UniProtKB/Swiss-Prot
    E9QLW5, P09535
    Conserved Domains (2) summary
    cd04368
    Location:28 → 91
    IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
    pfam08365
    Location:112 → 166
    IGF2_C; Insulin-like growth factor II E-peptide

  2. XM_006508487.1 → XP_006508550.1  insulin-like growth factor II isoform X1

    See identical proteins and their annotated locations for XP_006508550.1

    UniProtKB/Swiss-Prot
    E9QLW5, P09535
    Conserved Domains (2) summary
    cd04368
    Location:28 → 91
    IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
    pfam08365
    Location:112 → 166
    IGF2_C; Insulin-like growth factor II E-peptide

  3. XM_030242159.1 → XP_030098019.1  insulin-like growth factor II isoform X2

    Conserved Domains (1) summary
    cd04368
    Location:39 → 102
    IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...