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ACADVL acyl-CoA dehydrogenase very long chain [Homo sapiens (human)] - Gene - NCBI

Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (7217125..7225266)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (7118036..7126177)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (7120444..7128585)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007975.1 RefSeqGene

    Range
    5105..10433
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000018.4 → NP_000009.1  very long-chain specific acyl-CoA dehydrogenase, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_000009.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes isoform 1.
    Source sequence(s)
    BC000399
    Consensus CDS
    CCDS11090.1
    UniProtKB/Swiss-Prot
    B4DEB6, F5H2A9, O76056, P49748, Q8WUL0
    UniProtKB/TrEMBL
    Q53HR2
    Related
    ENSP00000349297.5, ENST00000356839.10
    Conserved Domains (1) summary
    cd01161
    Location:72 → 481
    VLCAD; Very long chain acyl-CoA dehydrogenase

  2. NM_001033859.3 → NP_001029031.1  very long-chain specific acyl-CoA dehydrogenase, mitochondrial isoform 2 precursor

    See identical proteins and their annotated locations for NP_001029031.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The resulting (isoform 2) is shorter, compared to isoform 1.
    Source sequence(s)
    BC020218, BP387474
    Consensus CDS
    CCDS42249.1
    UniProtKB/TrEMBL
    Q53HR2
    Related
    ENSP00000344152.5, ENST00000350303.9
    Conserved Domains (2) summary
    cd01161
    Location:50 → 459
    VLCAD; Very long chain acyl-CoA dehydrogenase
    COG1960
    Location:80 → 451
    CaiA; Acyl-CoA dehydrogenase related to the alkylation response protein AidB [Lipid transport and metabolism]

  3. NM_001270447.2 → NP_001257376.1  very long-chain specific acyl-CoA dehydrogenase, mitochondrial isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (3) is longer and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC120057, AK293549, BC000399, BP387474
    Consensus CDS
    CCDS58509.1
    UniProtKB/TrEMBL
    Q53HR2
    Related
    ENSP00000438689.2, ENST00000543245.6
    Conserved Domains (2) summary
    cd01161
    Location:95 → 504
    VLCAD; Very long chain acyl-CoA dehydrogenase
    COG1960
    Location:125 → 496
    CaiA; Acyl-CoA dehydrogenase related to the alkylation response protein AidB [Lipid transport and metabolism]

  4. NM_001270448.2 → NP_001257377.1  very long-chain specific acyl-CoA dehydrogenase, mitochondrial isoform 4

    See identical proteins and their annotated locations for NP_001257377.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has an additional segment in the 5' exon, compared to variant 1. The 5'-most supported initiation codon, as used in variant 1, is associated with a weak Kozak sequence and a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream AUG, and result in an isoform (4), which is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AK056083, BP387474
    UniProtKB/TrEMBL
    B3KPA6, Q53HR2
    Conserved Domains (2) summary
    cd01161
    Location:1 → 405
    VLCAD; Very long chain acyl-CoA dehydrogenase
    COG1960
    Location:26 → 397
    CaiA; Acyl-CoA dehydrogenase related to the alkylation response protein AidB [Lipid transport and metabolism]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    7217125..7225266
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006721516.4 → XP_006721579.2  very long-chain specific acyl-CoA dehydrogenase, mitochondrial isoform X1

    UniProtKB/TrEMBL
    Q53HR2
    Conserved Domains (2) summary
    cd01161
    Location:72 → 481
    VLCAD; Very long chain acyl-CoA dehydrogenase
    COG1960
    Location:102 → 473
    CaiA; Acyl-CoA dehydrogenase related to the alkylation response protein AidB [Lipid transport and metabolism]

  2. XM_011523830.3 → XP_011522132.1  very long-chain specific acyl-CoA dehydrogenase, mitochondrial isoform X3

    UniProtKB/TrEMBL
    Q53HR2
    Conserved Domains (2) summary
    cd01161
    Location:72 → 478
    VLCAD; Very long chain acyl-CoA dehydrogenase
    COG1960
    Location:102 → 473
    CaiA; Acyl-CoA dehydrogenase related to the alkylation response protein AidB [Lipid transport and metabolism]

  3. XM_011523829.3 → XP_011522131.1  very long-chain specific acyl-CoA dehydrogenase, mitochondrial isoform X2

    UniProtKB/TrEMBL
    Q53HR2
    Conserved Domains (2) summary
    cd01161
    Location:72 → 478
    VLCAD; Very long chain acyl-CoA dehydrogenase
    COG1960
    Location:102 → 473
    CaiA; Acyl-CoA dehydrogenase related to the alkylation response protein AidB [Lipid transport and metabolism]

  4. XM_047435932.1 → XP_047291888.1  very long-chain specific acyl-CoA dehydrogenase, mitochondrial isoform X5

  5. XM_047435931.1 → XP_047291887.1  very long-chain specific acyl-CoA dehydrogenase, mitochondrial isoform X4

    UniProtKB/TrEMBL
    Q53HR2

RNA

  1. XR_007065296.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    7118036..7126177
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054315978.1 → XP_054171953.1  very long-chain specific acyl-CoA dehydrogenase, mitochondrial isoform X1

    UniProtKB/TrEMBL
    Q53HR2

  2. XM_054315980.1 → XP_054171955.1  very long-chain specific acyl-CoA dehydrogenase, mitochondrial isoform X3

    UniProtKB/TrEMBL
    Q53HR2

  3. XM_054315979.1 → XP_054171954.1  very long-chain specific acyl-CoA dehydrogenase, mitochondrial isoform X2

    UniProtKB/TrEMBL
    Q53HR2

  4. XM_054315982.1 → XP_054171957.1  very long-chain specific acyl-CoA dehydrogenase, mitochondrial isoform X5

  5. XM_054315981.1 → XP_054171956.1  very long-chain specific acyl-CoA dehydrogenase, mitochondrial isoform X4

    UniProtKB/TrEMBL
    Q53HR2

RNA

  1. XR_008484816.1 RNA Sequence