pmc.ncbi.nlm.nih.gov

The use of intravenous immune globulin in multiple myeloma

. 1994 Jul;97(Suppl 1):21–24.

Abstract

Patients with multiple myeloma suffer from serious bacterial infections throughout the course of the disease. This is probably associated with reduced polyclonal immunoglobulin synthesis. Prophylactic intravenous immune globulin (IVIG) reduces the incidence and recurrence of these infections in the stable phase of the disease. Infections at times of induction chemotherapy and/or relapse have a wider range of causative organisms. Such susceptibility may be associated with abnormal phagocytic function following chemotherapy.

21

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Durie B. G., Salmon S. E. A clinical staging system for multiple myeloma. Correlation of measured myeloma cell mass with presenting clinical features, response to treatment, and survival. Cancer. 1975 Sep;36(3):842–854. doi: 10.1002/1097-0142(197509)36:3<842::aid-cncr2820360303>3.0.co;2-u. [DOI] [PubMed] [Google Scholar]
  2. FAHEY J. L., SCOGGINS R., UTZ J. P., SZWED C. F. INFECTION, ANTIBODY RESPONSE AND GAMMA GLOBULIN COMPONENTS IN MULTIPLE MYELOMA AND MACROGLOBULINEMIA. Am J Med. 1963 Nov;35:698–707. doi: 10.1016/0002-9343(63)90140-2. [DOI] [PubMed] [Google Scholar]
  3. Perri R. T., Hebbel R. P., Oken M. M. Influence of treatment and response status on infection risk in multiple myeloma. Am J Med. 1981 Dec;71(6):935–940. doi: 10.1016/0002-9343(81)90303-x. [DOI] [PubMed] [Google Scholar]
  4. Reinhart W. H., Berchtold P. E. Effect of high-dose intravenous immunoglobulin therapy on blood rheology. Lancet. 1992 Mar 14;339(8794):662–664. doi: 10.1016/0140-6736(92)90806-e. [DOI] [PubMed] [Google Scholar]
  5. Savage D. G., Lindenbaum J., Garrett T. J. Biphasic pattern of bacterial infection in multiple myeloma. Ann Intern Med. 1982 Jan;96(1):47–50. doi: 10.7326/0003-4819-96-1-47. [DOI] [PubMed] [Google Scholar]
  6. Schifferli J., Leski M., Favre H., Imbach P., Nydegger U., Davies K. High-dose intravenous IgG treatment and renal function. Lancet. 1991 Feb 23;337(8739):457–458. doi: 10.1016/0140-6736(91)93395-p. [DOI] [PubMed] [Google Scholar]
  7. Twomey J. J. Infections complicating multiple myeloma and chronic lymphocytic leukemia. Arch Intern Med. 1973 Oct;132(4):562–565. [PubMed] [Google Scholar]