Bacterial meningitis in children - PubMed

Review

Bacterial meningitis in children

Xavier Sáez-Llorens et al. Lancet. 2003.

Abstract

This review comprises aspects of the epidemiology, microbiology, pathophysiology, clinical manifestations, diagnosis, management, prognosis, and prevention of bacterial meningitis, with emphasis on the paediatric population. The beginning of this millennium has witnessed the virtual disappearance of Haemophilus invasive disease in some countries, emergence of pneumococcal strains that are resistant to multiple antibiotics, isolation of pneumococci with tolerance to vancomycin, outbreaks and clusters of meningococcal meningitis in several geographical areas, and intense research in development of effective conjugate pneumococcal and meningococcal vaccines. Bacterial meningitis has become an uncommon disease in the developed world. Unfortunately, because of limited economic resources and poor living conditions, many developing countries are still affected by the devastating consequences of this life-threatening systemic infection. Basic and clinical research is needed to discover new antimicrobial and anti-inflammatory agents to improve outcome from disease. Novel strategies are needed to distribute and implement effective vaccines worldwide to prevent bacterial meningitis.

Similar articles

• Bacterial meningitis.

  Heckenberg SG, Brouwer MC, van de Beek D. Heckenberg SG, et al. Handb Clin Neurol. 2014;121:1361-75. doi: 10.1016/B978-0-7020-4088-7.00093-6. Handb Clin Neurol. 2014. PMID: 24365425 Review.

• Bacterial meningitis in children.

  Chávez-Bueno S, McCracken GH Jr. Chávez-Bueno S, et al. Pediatr Clin North Am. 2005 Jun;52(3):795-810, vii. doi: 10.1016/j.pcl.2005.02.011. Pediatr Clin North Am. 2005. PMID: 15925663 Review.

• Pneumococcal meningitis in adults: new approaches to management and prevention.

  Weisfelt M, de Gans J, van der Poll T, van de Beek D. Weisfelt M, et al. Lancet Neurol. 2006 Apr;5(4):332-42. doi: 10.1016/S1474-4422(06)70409-4. Lancet Neurol. 2006. PMID: 16545750 Review.

• New diagnostic and therapeutic options in bacterial meningitis in infants and children.

  Kim KS. Kim KS. Minerva Pediatr. 2009 Oct;61(5):531-48. Minerva Pediatr. 2009. PMID: 19794379 Review.

• The implications of vaccines for prevention of bacterial meningitis.

  Riordan A. Riordan A. Curr Opin Neurol. 2010 Jun;23(3):319-24. doi: 10.1097/WCO.0b013e3283381751. Curr Opin Neurol. 2010. PMID: 20173637 Review.

Cited by

• Development and Optimization of a Homemade ELISA Kit for Detection of Antibodies Against Haemophilus influenzae Type b.

  Mousavi SF, Fatemi S, Siadat SD, Zahraei SM, Nikanpour E, Malekan MA, Khabiri AR, Janani AR. Mousavi SF, et al. Jundishapur J Microbiol. 2016 Feb 17;9(5):e30629. doi: 10.5812/jjm.30629. eCollection 2016 May. Jundishapur J Microbiol. 2016. PMID: 27540453 Free PMC article.

• The usefulness of serum delta neutrophil index for differentiating bacterial and viral meningitis in the emergency department.

  Lee JW, Park CI, Kim HI, Kim OH, Cha KC, Kim H, Lee KH, Hwang SO, Cha YS. Lee JW, et al. Clin Exp Emerg Med. 2016 Jun 30;3(2):95-99. doi: 10.15441/ceem.15.095. eCollection 2016 Jun. Clin Exp Emerg Med. 2016. PMID: 27752624 Free PMC article.

• Rapid diagnosis of bacterial meningitis by real-time PCR and fluorescence in situ hybridization.

  Poppert S, Essig A, Stoehr B, Steingruber A, Wirths B, Juretschko S, Reischl U, Wellinghausen N. Poppert S, et al. J Clin Microbiol. 2005 Jul;43(7):3390-7. doi: 10.1128/JCM.43.7.3390-3397.2005. J Clin Microbiol. 2005. PMID: 16000464 Free PMC article.

• Antimicrobial Resistance Pattern of Bacterial Meningitis Among Patients in Quetta, Pakistan.

  Ali SA, Taj MK, Ali SH. Ali SA, et al. Infect Drug Resist. 2021 Dec 1;14:5107-5120. doi: 10.2147/IDR.S339231. eCollection 2021. Infect Drug Resist. 2021. PMID: 34880636 Free PMC article.

• A prospective study of etiology of childhood acute bacterial meningitis, Turkey.

  Ceyhan M, Yildirim I, Balmer P, Borrow R, Dikici B, Turgut M, Kurt N, Aydogan A, Ecevit C, Anlar Y, Gulumser O, Tanir G, Salman N, Gurler N, Hatipoglu N, Hacimustafaoglu M, Celebi S, Coskun Y, Alhan E, Celik U, Camcioglu Y, Secmeer G, Gur D, Gray S. Ceyhan M, et al. Emerg Infect Dis. 2008 Jul;14(7):1089-96. doi: 10.3201/eid1407.070938. Emerg Infect Dis. 2008. PMID: 18598630 Free PMC article.

Publication types

MeSH terms