pubmed.ncbi.nlm.nih.gov

Effects of a novel formulation of essential oils on glucose-insulin metabolism in diabetic and hypertensive rats: a pilot study - PubMed

Effects of a novel formulation of essential oils on glucose-insulin metabolism in diabetic and hypertensive rats: a pilot study

N Talpur et al. Diabetes Obes Metab. 2005 Mar.

Abstract

Background: Insulin resistance and its most severe form type 2 diabetes mellitus are rapidly increasing throughout the world. It is generally recognized that natural products with a long history of safety can increase insulin sensitivity.

Aims: The present investigation examined the ability of various combinations of essential oils such as fenugreek, cinnamon, cumin, oregano, etc. to enhance insulin sensitivity. As a first approximation, we examined the effects of these natural products on Zucker fatty rats (ZFRs), a model of obesity and insulin resistance, and spontaneously hypertensive rats (SHRs), a model of genetic hypertension.

Material and methods: Water or essential oils were given orally via droplets, and insulin sensitivity was estimated by systolic blood pressure (SBP) changes and circulating glucose and/or insulin concentrations.

Results: We have found that the ability to alter SBP in rat models is the most sensitive early index of insulin sensitivity. The combined essential oils lowered circulating glucose levels and SBP in both ZFRs and SHRs, suggesting that these natural products are enhancing insulin sensitivity. The second series of studies examined two additional combinations of essential oils along with the original formula. The major differences were in the types and proportions of individual oils contributing to a given formula.

Conclusions: Although all the three formulae decreased SBP in ZFRs, one of the formulae was more effective than the others in lowering circulating glucose in the glucose tolerance testing. Accordingly, some essential oils may be added to the long list of natural products that can affect insulin sensitivity.

PubMed Disclaimer

Cited by

The Effect of Cumin cyminum L. Plus Lime Administration on Weight Loss and Metabolic Status in Overweight Subjects: A Randomized Double-Blind Placebo-Controlled Clinical Trial.
Taghizadeh M, Memarzadeh MR, Abedi F, Sharifi N, Karamali F, Fakhrieh Kashan Z, Asemi Z. Taghizadeh M, et al. Iran Red Crescent Med J. 2016 May 23;18(8):e34212. doi: 10.5812/ircmj.34212. eCollection 2016 Aug. Iran Red Crescent Med J. 2016. PMID: 27781121 Free PMC article.
Pharmacology of Natural Volatiles and Essential Oils in Food, Therapy, and Disease Prophylaxis.
Sadgrove NJ, Padilla-González GF, Leuner O, Melnikovova I, Fernandez-Cusimamani E. Sadgrove NJ, et al. Front Pharmacol. 2021 Oct 21;12:740302. doi: 10.3389/fphar.2021.740302. eCollection 2021. Front Pharmacol. 2021. PMID: 34744723 Free PMC article. Review.
Platelet microparticles contribute to aortic vascular endothelial injury in diabetes via the mTORC1 pathway.
Wang GH, Ma KL, Zhang Y, Hu ZB, Liu L, Lu J, Chen PP, Lu CC, Ruan XZ, Liu BC. Wang GH, et al. Acta Pharmacol Sin. 2019 Apr;40(4):468-476. doi: 10.1038/s41401-018-0186-4. Epub 2018 Nov 16. Acta Pharmacol Sin. 2019. PMID: 30446735 Free PMC article.
The Beneficial Effects of Essential Oils in Anti-Obesity Treatment.
De Blasio A, D'Anneo A, Lauricella M, Emanuele S, Giuliano M, Pratelli G, Calvaruso G, Carlisi D. De Blasio A, et al. Int J Mol Sci. 2021 Oct 31;22(21):11832. doi: 10.3390/ijms222111832. Int J Mol Sci. 2021. PMID: 34769261 Free PMC article. Review.
Improved Insulin Resistance and Lipid Metabolism by Cinnamon Extract through Activation of Peroxisome Proliferator-Activated Receptors.
Sheng X, Zhang Y, Gong Z, Huang C, Zang YQ. Sheng X, et al. PPAR Res. 2008;2008:581348. doi: 10.1155/2008/581348. Epub 2008 Dec 11. PPAR Res. 2008. PMID: 19096709 Free PMC article.

Effects of a novel formulation of essential oils on glucose-insulin metabolism in diabetic and hypertensive rats: a pilot study - PubMed