Max Schultze (1865), G. Bizzozero (1882) and the discovery of the platelet - PubMed

Max Schultze (1865), G. Bizzozero (1882) and the discovery of the platelet

Douglas B Brewer. Br J Haematol. 2006 May.

Free article

Abstract

Max Schultze published the first accurate and convincing description of platelets as part of a study devoted mainly to the white blood cells in 1865. He recognised them as a normal constituent of the blood and 'enthusiastically recommended' them as an object for further study by 'those concerned with the in-depth study of the blood of humans'. In 1882, Bizzozero demonstrated the value of this recommendation in his much more comprehensive study. He observed them microscopically in the circulating blood of living animals and in the blood removed from the blood vessels. In well-planned experiments, he showed that they were the first component of the blood to adhere to damaged blood vessel walls in vivo and, in vitro, that they were the first components of the blood to adhere to threads that subsequently became covered with fibrin.

Similar articles

• Giulio Bizzozero and the discovery of platelets.

  Ribatti D, Crivellato E. Ribatti D, et al. Leuk Res. 2007 Oct;31(10):1339-41. doi: 10.1016/j.leukres.2007.02.008. Epub 2007 Mar 26. Leuk Res. 2007. PMID: 17383722

• Bizzozero and the discovery of the blood platelet.

  Coller BS. Coller BS. Lancet. 1984 Apr 7;1(8380):804. doi: 10.1016/s0140-6736(84)91330-8. Lancet. 1984. PMID: 6143133 No abstract available.

• Platelet adhesion and aggregation and fibrin formation in flowing blood: a historical contribution by Giulio Bizzozero.

  de Gaetano G, Cerletti C. de Gaetano G, et al. Platelets. 2002 Mar;13(2):85-9. doi: 10.1080/09537100220122457. Platelets. 2002. PMID: 11897044

• Platelet adhesion.

  Packham MA, Mustard JF. Packham MA, et al. Prog Hemost Thromb. 1984;7:211-88. Prog Hemost Thromb. 1984. PMID: 6397767 Review.

• The vessel wall and its interactions.

  Wagner DD, Frenette PS. Wagner DD, et al. Blood. 2008 Jun 1;111(11):5271-81. doi: 10.1182/blood-2008-01-078204. Blood. 2008. PMID: 18502843 Free PMC article. Review.

Cited by

• Optical uncaging of ADP reveals the early calcium dynamics in single, freely moving platelets.

  Spiryova DV, Vorobev AY, Klimontov VV, Koroleva EA, Moskalensky AE. Spiryova DV, et al. Biomed Opt Express. 2020 May 27;11(6):3319-3330. doi: 10.1364/BOE.392745. eCollection 2020 Jun 1. Biomed Opt Express. 2020. PMID: 32637257 Free PMC article.

• Is autologous platelet activation the key step in ovarian therapy for fertility recovery and menopause reversal?

  Rickers NS, Sills ES. Rickers NS, et al. Biomedicine (Taipei). 2022 Dec 1;12(4):1-8. doi: 10.37796/2211-8039.1380. eCollection 2022. Biomedicine (Taipei). 2022. PMID: 36816178 Free PMC article. Review.

• Platelet-Neutrophil Interactions Are Lower in Cord Blood of Premature Newborns.

  Esiaba I, Angeles DM, Milford TM, Salto LM, Payne KJ, Kidder MY, Boskovic DS. Esiaba I, et al. Neonatology. 2019;115(2):149-155. doi: 10.1159/000494103. Epub 2018 Nov 27. Neonatology. 2019. PMID: 30481769 Free PMC article.

• Current concepts of platelet activation: possibilities for therapeutic modulation of heterotypic vs. homotypic aggregation.

  Passacquale G, Ferro A. Passacquale G, et al. Br J Clin Pharmacol. 2011 Oct;72(4):604-18. doi: 10.1111/j.1365-2125.2011.03906.x. Br J Clin Pharmacol. 2011. PMID: 21223359 Free PMC article. Review.

• Prevalence of Low Platelet Count and Identification of Associating Determinants and Genetic Polymorphism in Healthy Individuals of Upper Assam, India.

  Sultan N, Sharma SK. Sultan N, et al. Indian J Hematol Blood Transfus. 2019 Apr;35(2):332-338. doi: 10.1007/s12288-018-1007-0. Epub 2018 Sep 8. Indian J Hematol Blood Transfus. 2019. PMID: 30988572 Free PMC article.

Publication types

MeSH terms

Personal name as subject

LinkOut - more resources

• Full Text Sources

  • Ovid Technologies, Inc.
  • Wiley