Telomerase: a crucial player in HTLV-I-induced human T-cell leukemia - PubMed

Affiliations

• PMID: 17726237

Free article

Review

Telomerase: a crucial player in HTLV-I-induced human T-cell leukemia

Marcia Bellon et al. Cancer Genomics Proteomics. 2007 Jan-Feb.

Free article

Abstract

One in seven types of human cancer is associated with an oncogenic virus infection. Most human tumors have high telomerase activity but very short telomeres, yet the maintenance of these short telomeres is critical to avoid telomere end fusion or senescence and to support active proliferation. Oncogenic viruses have evolved a wide repertoire of strategies to stimulate telomerase functions at the transcriptional and post-transcriptional levels. Since telomerase activity is absent in somatic cells, the inhibition of telomerase is an attractive target for cancer therapeutics.

Similar articles

• Telomerase activity and telomere length as prognostic factors of adult T-cell leukemia.

  Kubuki Y, Suzuki M, Sasaki H, Toyama T, Yamashita K, Maeda K, Ido A, Matsuoka H, Okayama A, Nakanishi T, Tsubouchi H. Kubuki Y, et al. Leuk Lymphoma. 2005 Mar;46(3):393-9. doi: 10.1080/10428190400018349. Leuk Lymphoma. 2005. PMID: 15621829

• Regulation of telomerase and telomeres: human tumor viruses take control.

  Bellon M, Nicot C. Bellon M, et al. J Natl Cancer Inst. 2008 Jan 16;100(2):98-108. doi: 10.1093/jnci/djm269. Epub 2008 Jan 8. J Natl Cancer Inst. 2008. PMID: 18182620 Review.

• Telomeres and telomerase in leukaemia and lymphoma.

  Davison GM. Davison GM. Transfus Apher Sci. 2007 Aug;37(1):43-7. doi: 10.1016/j.transci.2007.04.006. Epub 2007 Sep 4. Transfus Apher Sci. 2007. PMID: 17766184 Review.

• Pharmacological intervention strategies for affecting telomerase activity: future prospects to treat cancer and degenerative disease.

  Tárkányi I, Aradi J. Tárkányi I, et al. Biochimie. 2008 Jan;90(1):156-72. doi: 10.1016/j.biochi.2007.09.002. Epub 2007 Sep 11. Biochimie. 2008. PMID: 17945408 Review.

• Telomere biology of pediatric cancer.

  Tabori U, Dome JS. Tabori U, et al. Cancer Invest. 2007 Apr-May;25(3):197-208. doi: 10.1080/07357900701208683. Cancer Invest. 2007. PMID: 17530490 Review.

Cited by

• Telomere Length, Proviral Load and Neurologic Impairment in HTLV-1 and HTLV-2-Infected Subjects.

  Usadi B, Bruhn R, Lin J, Lee TH, Blackburn E, Murphy EL. Usadi B, et al. Viruses. 2016 Aug 11;8(8):221. doi: 10.3390/v8080221. Viruses. 2016. PMID: 27529270 Free PMC article.

• Central role of PI3K in transcriptional activation of hTERT in HTLV-I-infected cells.

  Bellon M, Nicot C. Bellon M, et al. Blood. 2008 Oct 1;112(7):2946-55. doi: 10.1182/blood-2008-01-134692. Epub 2008 May 29. Blood. 2008. PMID: 18511807 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • HighWire