pubmed.ncbi.nlm.nih.gov

Gut modulatory, blood pressure lowering, diuretic and sedative activities of cardamom - PubMed

️Tue Jan 01 2008

. 2008 Feb 12;115(3):463-72.

doi: 10.1016/j.jep.2007.10.015. Epub 2007 Oct 22.

Affiliations

PMID: 18037596
DOI: 10.1016/j.jep.2007.10.015

Gut modulatory, blood pressure lowering, diuretic and sedative activities of cardamom

Anwarul Hassan Gilani et al. J Ethnopharmacol. 2008.

Abstract

Ethnopharmacological relevance: Cardamom (Elettaria cardamomum) is traditionally used in various gastrointestinal, cardiovascular and neuronal disorders.

Aim of the study: To rationalize cardamom use in constipation, colic, diarrhea, hypertension and as diuretic.

Materials and methods: Cardamom crude extract (Ec.Cr) was studied using in vitro and in vivo techniques.

Results: Ec.Cr caused atropine-sensitive stimulatory effect in isolated guinea-pig ileum at 3-10mg/ml. In rabbit jejunum preparations, Ec.Cr relaxed spontaneous and K+ (80 mM)-induced contractions as well as shifted Ca++ curves to right, like verapamil. Ec.Cr (3-100mg/kg) induced fall in the arterial blood pressure (BP) of anaesthetized rats, partially blocked in atropinized animals. In endothelium-intact rat aorta, Ec.Cr relaxed phenylephrine (1 microM)-induced contractions, partially antagonized by atropine and also inhibited K+ (80 mM) contractions. In guinea-pig atria, Ec.Cr exhibited a cardio-depressant effect. Ec.Cr (1-10mg/kg) produced diuresis in rats, accompanied by a saluretic effect. It enhanced pentobarbital-induced sleeping time in mice. Bio-assay directed fractionation revealed the separation of spasmogenic and spasmolytic components in the aqueous and organic fractions respectively.

Conclusion: These results indicate that cardamom exhibits gut excitatory and inhibitory effects mediated through cholinergic and Ca++ antagonist mechanisms respectively and lowers BP via combination of both pathways. The diuretic and sedative effects may offer added value in its use in hypertension and epilepsy.

PubMed Disclaimer

Cited by

The gastrointestinal irritation of polygala saponins and its potential mechanism in vitro and in vivo.
Wen L, Xia N, Tang P, Hong Y, Wang Z, Liu Y, Liu Y, Liu J, Li X. Wen L, et al. Biomed Res Int. 2015;2015:918048. doi: 10.1155/2015/918048. Epub 2015 Feb 1. Biomed Res Int. 2015. PMID: 25705699 Free PMC article.
Studies to Elucidate the Mechanism of Cardio Protective and Hypotensive Activities of Anogeissus acuminata (Roxb. ex DC.) in Rodents.
Saqib F, Arif Aslam M, Mujahid K, Marceanu L, Moga M, Ahmedah HT, Chicea L. Saqib F, et al. Molecules. 2020 Jul 30;25(15):3471. doi: 10.3390/molecules25153471. Molecules. 2020. PMID: 32751601 Free PMC article.
Peucedanum ostruthium Inhibits E-Selectin and VCAM-1 Expression in Endothelial Cells through Interference with NF-κB Signaling.
Lammel C, Zwirchmayr J, Seigner J, Rollinger JM, de Martin R. Lammel C, et al. Biomolecules. 2020 Aug 21;10(9):1215. doi: 10.3390/biom10091215. Biomolecules. 2020. PMID: 32825714 Free PMC article.
Protective Role of Phenolic Compounds from Whole Cardamom (Elettaria cardamomum (L.) Maton) against LPS-Induced Inflammation in Colon and Macrophage Cells.
Sreedharan S, Nair V, Cisneros-Zevallos L. Sreedharan S, et al. Nutrients. 2023 Jun 29;15(13):2965. doi: 10.3390/nu15132965. Nutrients. 2023. PMID: 37447289 Free PMC article.
Insights into mechanisms underlying the gut and airways modulatory effects of Swertia chirata.
Khan AU, Rahim A, Iqbal Z, Gilani AH. Khan AU, et al. J Nat Med. 2012 Jan;66(1):140-8. doi: 10.1007/s11418-011-0566-2. Epub 2011 Jul 27. J Nat Med. 2012. PMID: 21792726

Gut modulatory, blood pressure lowering, diuretic and sedative activities of cardamom - PubMed

Gut modulatory, blood pressure lowering, diuretic and sedative activities of cardamom

Abstract

Similar articles

Cited by

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Research Materials