Swine influenza virus: zoonotic potential and vaccination strategies for the control of avian and swine influenzas - PubMed

Affiliations

• PMID: 18269323
• DOI: 10.1086/524988

Review

Swine influenza virus: zoonotic potential and vaccination strategies for the control of avian and swine influenzas

Eileen Thacker et al. J Infect Dis. 2008.

Abstract

Influenza viruses are able to infect humans, swine, and avian species, and swine have long been considered a potential source of new influenza viruses that can infect humans. Swine have receptors to which both avian and mammalian influenza viruses bind, which increases the potential for viruses to exchange genetic sequences and produce new reassortant viruses in swine. A number of genetically diverse viruses are circulating in swine herds throughout the world and are a major cause of concern to the swine industry. Control of swine influenza is primarily through the vaccination of sows, to protect young pigs through maternally derived antibodies. However, influenza viruses continue to circulate in pigs after the decay of maternal antibodies, providing a continuing source of virus on a herd basis. Measures to control avian influenza in commercial poultry operations are dictated by the virulence of the virus. Detection of a highly pathogenic avian influenza (HPAI) virus results in immediate elimination of the flock. Low-pathogenic avian influenza viruses are controlled through vaccination, which is done primarily in turkey flocks. Maintenance of the current HPAI virus-free status of poultry in the United States is through constant surveillance of poultry flocks. Although current influenza vaccines for poultry and swine are inactivated and adjuvanted, ongoing research into the development of newer vaccines, such as DNA, live-virus, or vectored vaccines, is being done. Control of influenza virus infection in poultry and swine is critical to the reduction of potential cross-species adaptation and spread of influenza viruses, which will minimize the risk of animals being the source of the next pandemic.

Similar articles

• [Avian influenza: eradication from commercial poultry is still not in sight].

  Landman WJ, Schrier CC. Landman WJ, et al. Tijdschr Diergeneeskd. 2004 Dec 1;129(23):782-96. Tijdschr Diergeneeskd. 2004. PMID: 15624878 Review. Dutch.

• Avian and swine influenza viruses: our current understanding of the zoonotic risk.

  Van Reeth K. Van Reeth K. Vet Res. 2007 Mar-Apr;38(2):243-60. doi: 10.1051/vetres:2006062. Epub 2007 Jan 25. Vet Res. 2007. PMID: 17257572 Review.

• (Highly pathogenic) avian influenza as a zoonotic agent.

  Kalthoff D, Globig A, Beer M. Kalthoff D, et al. Vet Microbiol. 2010 Jan 27;140(3-4):237-45. doi: 10.1016/j.vetmic.2009.08.022. Epub 2009 Aug 26. Vet Microbiol. 2010. PMID: 19782482 Review.

• Influenza vaccines and vaccination strategies in birds.

  van den Berg T, Lambrecht B, Marché S, Steensels M, Van Borm S, Bublot M. van den Berg T, et al. Comp Immunol Microbiol Infect Dis. 2008 Mar;31(2-3):121-65. doi: 10.1016/j.cimid.2007.07.004. Epub 2007 Sep 24. Comp Immunol Microbiol Infect Dis. 2008. PMID: 17889937 Review.

• Generation and evaluation of the trivalent inactivated reassortant vaccine using human, avian, and swine influenza A viruses.

  Du N, Li W, Li Y, Liu S, Sui Y, Qu Z, Wang Y, Du Y, Xu B. Du N, et al. Vaccine. 2008 Jun 2;26(23):2912-8. doi: 10.1016/j.vaccine.2008.03.048. Epub 2008 Apr 11. Vaccine. 2008. PMID: 18448208

Cited by

• Inferring patterns of influenza transmission in swine from multiple streams of surveillance data.

  Strelioff CC, Vijaykrishna D, Riley S, Guan Y, Peiris JS, Lloyd-Smith JO. Strelioff CC, et al. Proc Biol Sci. 2013 May 8;280(1762):20130872. doi: 10.1098/rspb.2013.0872. Print 2013 Jul 7. Proc Biol Sci. 2013. PMID: 23658205 Free PMC article.

• Identification and Characterization of Swine Influenza Virus H1N1 Variants Generated in Vaccinated and Nonvaccinated, Challenged Pigs.

  López-Valiñas Á, Sisteré-Oró M, López-Serrano S, Baioni L, Darji A, Chiapponi C, Segalés J, Ganges L, Núñez JI. López-Valiñas Á, et al. Viruses. 2021 Oct 16;13(10):2087. doi: 10.3390/v13102087. Viruses. 2021. PMID: 34696517 Free PMC article.

• Surveillance strategy for early detection of unusual infectious disease events.

  Koopmans M. Koopmans M. Curr Opin Virol. 2013 Apr;3(2):185-91. doi: 10.1016/j.coviro.2013.02.003. Epub 2013 Apr 21. Curr Opin Virol. 2013. PMID: 23612329 Free PMC article. Review.

• Evolution of Swine Influenza Virus H3N2 in Vaccinated and Nonvaccinated Pigs after Previous Natural H1N1 Infection.

  López-Valiñas Á, Baioni L, Córdoba L, Darji A, Chiapponi C, Segalés J, Ganges L, Núñez JI. López-Valiñas Á, et al. Viruses. 2022 Sep 10;14(9):2008. doi: 10.3390/v14092008. Viruses. 2022. PMID: 36146814 Free PMC article.

• The influenza pandemic of 2009: lessons and implications.

  Shapshak P, Chiappelli F, Somboonwit C, Sinnott J. Shapshak P, et al. Mol Diagn Ther. 2011 Apr 1;15(2):63-81. doi: 10.1007/BF03256397. Mol Diagn Ther. 2011. PMID: 21623644 Review.

Publication types

MeSH terms

LinkOut - more resources

• Full Text Sources

  • Ovid Technologies, Inc.
  • Silverchair Information Systems

• Other Literature Sources

  • The Lens - Patent Citations Database

• Medical

  • MedlinePlus Health Information