The pharmacological management of violence in schizophrenia: a structured review - PubMed

Review

The pharmacological management of violence in schizophrenia: a structured review

Anya Topiwala et al. Expert Rev Neurother. 2011 Jan.

Abstract

Although the increased risk of violent behavior in individuals with schizophrenia is now well-established, there is considerable uncertainty in pharmacological strategies to reduce this risk. In this review, we performed a systematic search of three electronic databases from January 2000 to March 2010 of treatment research on the management of violence in schizophrenia. We identified eight randomized controlled trials. The main findings included the association of nonadherence to antipsychotic medication to violent outcomes, a specific anti-aggressive effect of clozapine and short-term benefits of adjunctive β-blockers. There was little evidence on the efficacy of adjunctive mood stabilizers, depot medication or electroconvulsive therapy. Future research should use validated outcomes, longer follow-up periods and investigate patients with comorbid substance misuse.

Similar articles

• The effects of clozapine on aggression and substance abuse in schizophrenic patients.

  Volavka J. Volavka J. J Clin Psychiatry. 1999;60 Suppl 12:43-6. J Clin Psychiatry. 1999. PMID: 10372611 Review.

• Violence among schizophrenia out-patients compliant with medication: prevalence and associated factors.

  Bobes J, Fillat O, Arango C. Bobes J, et al. Acta Psychiatr Scand. 2009 Mar;119(3):218-25. doi: 10.1111/j.1600-0447.2008.01302.x. Acta Psychiatr Scand. 2009. PMID: 19178395

• Substance abuse and the management of medication nonadherence in schizophrenia.

  Wilk J, Marcus SC, West J, Countis L, Hall R, Regier DA, Olfson M. Wilk J, et al. J Nerv Ment Dis. 2006 Jun;194(6):454-7. doi: 10.1097/01.nmd.0000221289.54911.63. J Nerv Ment Dis. 2006. PMID: 16772865

• Substance abuse in schizophrenia: a review.

  Buckley PF. Buckley PF. J Clin Psychiatry. 1998;59 Suppl 3:26-30. J Clin Psychiatry. 1998. PMID: 9541335 Review.

• Violence in schizophrenia and bipolar disorder.

  Volavka J. Volavka J. Psychiatr Danub. 2013 Mar;25(1):24-33. Psychiatr Danub. 2013. PMID: 23470603 Review.

Cited by

• Diagnosing and managing violence.

  Fetter JC. Fetter JC. Prim Care Companion CNS Disord. 2011;13(5):PCC.11br01144. doi: 10.4088/PCC.11br01144. Prim Care Companion CNS Disord. 2011. PMID: 22295257 Free PMC article.

• Comprehensive review on virtual reality for the treatment of violence: implications for youth with schizophrenia.

  Dellazizzo L, Potvin S, Bahig S, Dumais A. Dellazizzo L, et al. NPJ Schizophr. 2019 Jul 23;5(1):11. doi: 10.1038/s41537-019-0079-7. NPJ Schizophr. 2019. PMID: 31337763 Free PMC article. Review.

• Associations between β-blockers and psychiatric and behavioural outcomes: A population-based cohort study of 1.4 million individuals in Sweden.

  Molero Y, Kaddoura S, Kuja-Halkola R, Larsson H, Lichtenstein P, D'Onofrio BM, Fazel S. Molero Y, et al. PLoS Med. 2023 Jan 31;20(1):e1004164. doi: 10.1371/journal.pmed.1004164. eCollection 2023 Jan. PLoS Med. 2023. PMID: 36719888 Free PMC article.

• Pathways to aggression in schizophrenia affect results of treatment.

  Volavka J, Citrome L. Volavka J, et al. Schizophr Bull. 2011 Sep;37(5):921-9. doi: 10.1093/schbul/sbr041. Epub 2011 May 11. Schizophr Bull. 2011. PMID: 21562140 Free PMC article. Review.

• An evaluation of the use of olanzapine pamoate depot injection in seriously violent men with schizophrenia in a UK high-security hospital.

  Baruch N, Das M, Sharda A, Basu A, Bajorek T, Ross CC, Sengupta S, Larkin F, Young S. Baruch N, et al. Ther Adv Psychopharmacol. 2014 Oct;4(5):186-92. doi: 10.1177/2045125314531982. Ther Adv Psychopharmacol. 2014. PMID: 25360243 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Atypon
  • Ovid Technologies, Inc.

• Medical

  • MedlinePlus Health Information