Investigation of the neuroprotective action of saffron (Crocus sativus L.) in aluminum-exposed adult mice through behavioral and neurobiochemical assessment - PubMed

Investigation of the neuroprotective action of saffron (Crocus sativus L.) in aluminum-exposed adult mice through behavioral and neurobiochemical assessment

Zacharoula I Linardaki et al. Food Chem Toxicol. 2013 Feb.

Abstract

In the present study, the possible reversal effects of saffron against established aluminum (Al)-toxicity in adult mice, were investigated. Control, Al-treated (50 mg AlCl(3)/kg/day diluted in the drinking water for 5 weeks) and Al+saffron (Al-treatment as previously plus 60 mg saffron extract/kg/day intraperitoneally for the last 6 days), groups of male Balb-c mice were used. We assessed learning/memory, the activity of acetylcholinesterase [AChE, salt-(SS)/detergent-soluble(DS) isoforms], butyrylcholinesterase (BuChE, SS/DS isoforms), monoamine oxidase (MAO-A, MAO-B), the levels of lipid peroxidation (MDA) and reduced glutathione (GSH), in whole brain and cerebellum. Brain Al was determined by atomic absorption spectrometry, while, for the first time, crocetin, the main active metabolite of saffron, was determined in brain after intraperitoneal saffron administration by HPLC. Al intake caused memory impairment, significant decrease of AChE and BuChE activity, activation of brain MAO isoforms but inhibition of cerebellar MAO-B, significant elevation of brain MDA and significant reduction of GSH content. Although saffron extract co-administration had no effect on cognitive performance of mice, it reversed significantly the Al-induced changes in MAO activity and the levels of MDA and GSH. AChE activity was further significantly decreased in cerebral tissues of Al+saffron group. The biochemical changes support the neuroprotective potential of saffron under toxicity.

Similar articles

• Saffron (Crocus sativus L.) Tea Intake Prevents Learning/Memory Defects and Neurobiochemical Alterations Induced by Aflatoxin B₁ Exposure in Adult Mice.

  Linardaki ZI, Lamari FN, Margarity M. Linardaki ZI, et al. Neurochem Res. 2017 Oct;42(10):2743-2754. doi: 10.1007/s11064-017-2283-z. Epub 2017 May 2. Neurochem Res. 2017. PMID: 28462452

• Memory enhancing effects of saffron in aged mice are correlated with antioxidant protection.

  Papandreou MA, Tsachaki M, Efthimiopoulos S, Cordopatis P, Lamari FN, Margarity M. Papandreou MA, et al. Behav Brain Res. 2011 Jun 1;219(2):197-204. doi: 10.1016/j.bbr.2011.01.007. Epub 2011 Jan 14. Behav Brain Res. 2011. PMID: 21238492

• Effect of a polyphenol-rich wild blueberry extract on cognitive performance of mice, brain antioxidant markers and acetylcholinesterase activity.

  Papandreou MA, Dimakopoulou A, Linardaki ZI, Cordopatis P, Klimis-Zacas D, Margarity M, Lamari FN. Papandreou MA, et al. Behav Brain Res. 2009 Mar 17;198(2):352-8. doi: 10.1016/j.bbr.2008.11.013. Epub 2008 Nov 17. Behav Brain Res. 2009. PMID: 19056430

• Effects of saffron extract and its constituent crocin on learning behaviour and long-term potentiation.

  Abe K, Saito H. Abe K, et al. Phytother Res. 2000 May;14(3):149-52. doi: 10.1002/(sici)1099-1573(200005)14:3<149::aid-ptr665>3.0.co;2-5. Phytother Res. 2000. PMID: 10815004 Review.

• A Perspective on Crocus sativus L. (Saffron) Constituent Crocin: A Potent Water-Soluble Antioxidant and Potential Therapy for Alzheimer's Disease.

  Finley JW, Gao S. Finley JW, et al. J Agric Food Chem. 2017 Feb 8;65(5):1005-1020. doi: 10.1021/acs.jafc.6b04398. Epub 2017 Jan 31. J Agric Food Chem. 2017. PMID: 28098452 Review.

Cited by

• The effects of Crocus sativus (saffron) and its constituents on nervous system: A review.

  Khazdair MR, Boskabady MH, Hosseini M, Rezaee R, M Tsatsakis A. Khazdair MR, et al. Avicenna J Phytomed. 2015 Sep-Oct;5(5):376-91. Avicenna J Phytomed. 2015. PMID: 26468457 Free PMC article. Review.

• Enhancement of Antinociceptive Effect by Co-administration of Amitriptyline and Crocus Sativus in a Rat Model of Neuropathic Pain.

  Amin B, Hosseini S, Hosseinzadeh H. Amin B, et al. Iran J Pharm Res. 2017 Winter;16(1):187-200. Iran J Pharm Res. 2017. PMID: 28496474 Free PMC article.

• Ameliorative effect of saffron aqueous extract on hyperglycemia, hyperlipidemia, and oxidative stress on diabetic encephalopathy in streptozotocin induced experimental diabetes mellitus.

  Samarghandian S, Azimi-Nezhad M, Samini F. Samarghandian S, et al. Biomed Res Int. 2014;2014:920857. doi: 10.1155/2014/920857. Epub 2014 Jul 9. Biomed Res Int. 2014. PMID: 25114929 Free PMC article.

• An In Vitro Study of Saffron Carotenoids: The Effect of Crocin Extracts and Dimethylcrocetin on Cancer Cell Lines.

  Hatziagapiou K, Nikola O, Marka S, Koniari E, Kakouri E, Zografaki ME, Mavrikou SS, Kanakis C, Flemetakis E, Chrousos GP, Kintzios S, Lambrou GI, Kanaka-Gantenbein C, Tarantilis PA. Hatziagapiou K, et al. Antioxidants (Basel). 2022 May 28;11(6):1074. doi: 10.3390/antiox11061074. Antioxidants (Basel). 2022. PMID: 35739971 Free PMC article.

• Potential therapeutic effects of crocin.

  Pourmousavi L, Asadi RH, Zehsaz F, Jadidi RP. Pourmousavi L, et al. Naunyn Schmiedebergs Arch Pharmacol. 2024 Oct;397(10):7395-7420. doi: 10.1007/s00210-024-03131-6. Epub 2024 May 17. Naunyn Schmiedebergs Arch Pharmacol. 2024. PMID: 38758225 Review.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Elsevier Science

• Other Literature Sources

  • scite Smart Citations

• Medical

  • MedlinePlus Health Information