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Consumption of Chinese tea-flavor liquor improves circulating insulin levels without affecting hepatic lipid metabolism-related gene expression in Sprague-Dawley rats - PubMed

Consumption of Chinese tea-flavor liquor improves circulating insulin levels without affecting hepatic lipid metabolism-related gene expression in Sprague-Dawley rats

Ju-Sheng Zheng et al. ScientificWorldJournal. 2013.

Abstract

Objective: To examine the effect of two Chinese liquors with quite different nonalcoholic components on insulin sensitivity, tissue polyunsaturated fatty acids (PUFA), and hepatic lipid metabolism in SD rats.

Methods: Thirty-three SD rats were randomized into four groups and maintained in each treatment for 10 weeks: Chinese tea-flavor liquor (TFL, n=9), traditional Chinese liquor (TCL, n=8), ethanol control (EC, n=8), and water control (WC, n=8).

Results: TFL significantly decreased plasma insulin (P=0.009) and marginally decreased Homeostatic Model Assessment-Insulin Resistance (HOMA-IR) (P=0.05), compared with WC. Hepatic total and n-6 PUFA compositions were significantly decreased in TFL, TCL, and EC groups compared with WC group (P<0.05). TFL significantly increased kidney n-6 PUFA (P=0.05) and total PUFA (P=0.039), compared with EC group. EC group showed significant higher gene expressions of acetyl-CoA carboxylase and steroid response element-binding protein (1c and 2), while there were no significant differences of these gene expressions in TFL or TCL group compared with WC.

Conclusions: TFL has a beneficial effect on metabolic disorder in relation to improved circulating insulin levels without affecting hepatic lipid metabolism-related gene expressions in rats.

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Figures

Figure 1
Figure 1

Effect of ethanol treatment on the AMPK-related lipid metabolism pathway. SREBP: steroid response element-binding protein; AMPK: adenosine monophosphate-dependent protein kinase; PPAR-α: peroxisome proliferator-activated receptor alpha; ACC: acetyl-CoA carboxylase.

Figure 2
Figure 2

TFL and TCL consumption and plasma insulin and HOMA-IR levels. (a) Effect of TFL and TCL consumption on plasma insulin; (b) Effect of TFL and TCL consumption on HOMA-IR. TFL: tea-flavor liquor; TCL: traditional Chinese liquor; EC: ethanol control; WC: water control.

Figure 3
Figure 3

Relative mRNA expressions of key lipid metabolism-related genes. Acaca: acetyl-coenzyme A carboxylase alpha; Srebf1: sterol regulatory element binding transcription factor 1; Srebf2: sterol regulatory element binding transcription factor 2; TFL: tea-flavor liquor; TCL: traditional Chinese liquor; EC: ethanol control; WC: water control.

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