Administration of Fenugreek Seed Extract Produces Better Effects in Glibenclamide-Induced Inhibition in Hepatic Lipid Peroxidation: An in vitro Study - PubMed
. 2019 Apr;25(4):278-284.
doi: 10.1007/s11655-015-1793-z. Epub 2015 Mar 6.
Affiliations
- PMID: 25749901
- DOI: 10.1007/s11655-015-1793-z
Administration of Fenugreek Seed Extract Produces Better Effects in Glibenclamide-Induced Inhibition in Hepatic Lipid Peroxidation: An in vitro Study
Sharma Neha et al. Chin J Integr Med. 2019 Apr.
Abstract
Objective: To evaluate the comparative effects of fenugreek (Trigonella foenum graecum) seed extract (FSE) alone and in combination with an antidiabetic conventional medicine, glibenclamide (GLB), on the inhibition of in vitro lipid peroxidation (LPO) in liver, the major target organ of a drug.
Methods: LPO was induced by ferrous sulphate (FeSo4), hydrogen peroxide (H2O2) and carbon tetrachloride (CCl4) and the effects of test seed extract and/or GLB were evaluated.
Results: While FeSo4, H2O2 and CCl4 markedly enhanced the hepatic LPO, simultaneous administration of FSE reduced it in a concentration dependent manner. However, when both FSE and GLB were added to the incubation mixture, chemically induced hepatic LPO was further inhibited. The test extract also exhibited high antioxidative activity in 1,1-diphenyl-2-picrylhydrazyl radical and in 2,2'-azinobis, 3-ethylbenzothiazoline-6-sulphonic acid radical scavenging assays.
Conclusion: FSE therapy in moderate concentration along with a hypoglycemic drug may prove to be advantageous in ameliorating diabetes mellitus and other diseases that are LPO mediated.
Keywords: antioxidant activity; fenugreek; glibenclamide; lipid peroxidation.
Similar articles
-
Mbarki S, Alimi H, Bouzenna H, Elfeki A, Hfaiedh N. Mbarki S, et al. Biomed Pharmacother. 2017 Apr;88:19-26. doi: 10.1016/j.biopha.2016.12.078. Epub 2017 Jan 13. Biomed Pharmacother. 2017. PMID: 28092841
-
Protective effect of fenugreek (Trigonella foenum graecum) seeds in experimental ethanol toxicity.
Thirunavukkarasu V, Anuradha CV, Viswanathan P. Thirunavukkarasu V, et al. Phytother Res. 2003 Aug;17(7):737-43. doi: 10.1002/ptr.1198. Phytother Res. 2003. PMID: 12916070
-
Antioxidant activity of Caesalpinia digyna root.
Srinivasan R, Chandrasekar MJ, Nanjan MJ, Suresh B. Srinivasan R, et al. J Ethnopharmacol. 2007 Sep 5;113(2):284-91. doi: 10.1016/j.jep.2007.06.006. Epub 2007 Jun 26. J Ethnopharmacol. 2007. PMID: 17686593
-
Park D, Jeon JH, Kwon SC, Shin S, Jang JY, Jeong HS, Lee DI, Kim YB, Joo SS. Park D, et al. Biochem Cell Biol. 2009 Dec;87(6):943-52. doi: 10.1139/o09-065. Biochem Cell Biol. 2009. PMID: 19935880
-
Sankar P, Subhashree S, Sudharani S. Sankar P, et al. Eur Rev Med Pharmacol Sci. 2012 Jul;16 Suppl 3:10-7. Eur Rev Med Pharmacol Sci. 2012. PMID: 22957413
Cited by
-
Verma N, Usman K, Patel N, Jain A, Dhakre S, Swaroop A, Bagchi M, Kumar P, Preuss HG, Bagchi D. Verma N, et al. Food Nutr Res. 2016 Oct 11;60:32382. doi: 10.3402/fnr.v60.32382. eCollection 2016. Food Nutr Res. 2016. PMID: 27733237 Free PMC article.
-
Gupta RC, Chang D, Nammi S, Bensoussan A, Bilinski K, Roufogalis BD. Gupta RC, et al. Diabetol Metab Syndr. 2017 Jul 26;9:59. doi: 10.1186/s13098-017-0254-9. eCollection 2017. Diabetol Metab Syndr. 2017. PMID: 28770011 Free PMC article. Review.
-
Pharmacodynamic Interactions between Puerarin and Metformin in Type-2 Diabetic Rats.
Li Z, Wang S, Wang X, Gao P, Zhang S, Mo Y, Zhao D, Dai L. Li Z, et al. Molecules. 2022 Oct 24;27(21):7197. doi: 10.3390/molecules27217197. Molecules. 2022. PMID: 36364022 Free PMC article.
-
Vieira R, Souto SB, Sánchez-López E, Machado AL, Severino P, Jose S, Santini A, Fortuna A, García ML, Silva AM, Souto EB. Vieira R, et al. Pharmaceuticals (Basel). 2019 Oct 10;12(4):152. doi: 10.3390/ph12040152. Pharmaceuticals (Basel). 2019. PMID: 31658729 Free PMC article. Review.
References
MeSH terms
Substances
LinkOut - more resources
Full Text Sources