Assignment of human coagulation factor XII (fXII) to chromosome 5 by cDNA hybridization to DNA from somatic cell hybrids - PubMed

Assignment of human coagulation factor XII (fXII) to chromosome 5 by cDNA hybridization to DNA from somatic cell hybrids

F Citarella et al. Hum Genet. 1988 Dec.

Abstract

Human coagulation factor XII (fXII), a serine protease synthesized in liver and active in plasma, is involved in a wide variety of functions, including blood coagulation, fibrinolysis, bradykinin and complement activation. A complementary DNA (597 bp) encoding amino acid -16 to amino acid 183 of fXII protein was used to determine the chromosomal location of the fXII gene. DNAs from hamster-human somatic cell hybrids were digested with restriction enzymes and hybridized with the fXII cDNA. By the Southern method it was shown that restriction fragments able to hybridize to fXII cDNA are present only in DNA extracted from clones retaining human chromosome 5.

Similar articles

• Structural gene encoding human factor XII is located at 5q33-qter.

  Royle NJ, Nigli M, Cool D, MacGillivray RT, Hamerton JL. Royle NJ, et al. Somat Cell Mol Genet. 1988 Mar;14(2):217-21. doi: 10.1007/BF01534407. Somat Cell Mol Genet. 1988. PMID: 3162339

• Factor XII Shizuoka, a novel mutation (Ala392Thr) identified and characterized in a patient with congenital coagulation factor XII deficiency.

  Oguchi S, Ishii K, Moriki T, Takeshita E, Murata M, Ikeda Y, Watanabe K. Oguchi S, et al. Thromb Res. 2005;115(3):191-7. doi: 10.1016/j.thromres.2004.08.027. Thromb Res. 2005. PMID: 15617741

• Assignment of the human tyrosine aminotransferase gene to chromosome 16.

  Natt E, Kao FT, Rettenmeier R, Scherer G. Natt E, et al. Hum Genet. 1986 Mar;72(3):225-8. doi: 10.1007/BF00291882. Hum Genet. 1986. PMID: 2870018

• Estrogen induction and contact phase activation of human factor XII.

  Citarella F, Misiti S, Felici A, Farsetti A, Pontecorvi A, Fantoni A. Citarella F, et al. Steroids. 1996 Apr;61(4):270-6. doi: 10.1016/0039-128x(96)00037-2. Steroids. 1996. PMID: 8733013 Review.

Cited by

• Factor XII: what does it contribute to our understanding of the physiology and pathophysiology of hemostasis & thrombosis.

  Stavrou E, Schmaier AH. Stavrou E, et al. Thromb Res. 2010 Mar;125(3):210-5. doi: 10.1016/j.thromres.2009.11.028. Thromb Res. 2010. PMID: 20022081 Free PMC article. Review.

References

Publication types

MeSH terms

Substances