GTP interacts with the gamma-subunit of eukaryotic initiation factor eIF-2 - PubMed

GTP interacts with the gamma-subunit of eukaryotic initiation factor eIF-2

T V Kurzchalia et al. FEBS Lett. 1984.

Free article

Abstract

Eukaryotic initiation factor eIF-2 is an oligomeric protein consisting of three different subunits. During initiation of protein synthesis eIF-2 interacts with GTP, Met-tRNAf and 40 S ribosomal subunit. By affinity labeling with a photo-reactive GTP analogue it was shown that in the binary complex [eIF-2 X GTP] GTP is in contact with the gamma-subunit of eIF-2.

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