Vitamin D increases expression of the tyrosine hydroxylase gene in adrenal medullary cells - PubMed

Vitamin D increases expression of the tyrosine hydroxylase gene in adrenal medullary cells

E Puchacz et al. Brain Res Mol Brain Res. 1996 Feb.

Abstract

We examined expression of the 1,25-dihydroxyvitamin D3 [1,25-(OH)2 D3] receptors in chromaffin cells of the adrenal medulla and the effects of 1,25(OH)2 D3 on expression of the tyrosine hydroxylase (TH) gene. Accumulation of 1,25(OH)2 D3 in the nuclei of adrenal medullary cells, but not in the adrenal cortex, was observed in mice intravenously injected with radioactively labeled hormone. 1,25(OH)2 D3 produced concentration-dependent increases in the TH mRNA levels in cultured bovine adrenal medullary cells (BAMC). The maximal increases (2-3-fold) occurred at 10(-8) M 1,25(OH)2 D3. Combined treatment with 1,25(OH)2 D3 and 20 microM nicotine had no additive effect on TH mRNA levels suggesting that transsynaptic (nicotinic) and vitamin D (hormonal) stimulation of TH gene expression are mediated through converging mechanisms. Induction of TH mRNA by 1,25(OH)2 D3 was not affected by calcium antagonist TMB-8. By increasing expression of the rate limiting enzyme in the catecholamine biosynthetic pathway, 1,25-(OH)2 D3 may participate in the regulation of catecholamine production in adrenal chromaffin cells. This regulation provides mechanisms through which 1,25(OH)2 D3 may control response and adaptation to stress.

Similar articles

• Regulation of tyrosine hydroxylase gene expression in depolarized non-transformed bovine adrenal medullary cells: second messenger systems and promoter mechanisms.

  Stachowiak MK, Goc A, Hong JS, Poisner A, Jiang HK, Stachowiak EK. Stachowiak MK, et al. Brain Res Mol Brain Res. 1994 Mar;22(1-4):309-19. doi: 10.1016/0169-328x(94)90059-0. Brain Res Mol Brain Res. 1994. PMID: 7912405

• Basic fibroblast growth factor (bFGF) regulates tyrosine hydroxylase and proenkephalin mRNA levels in adrenal chromaffin cells.

  Puchacz E, Stachowiak EK, Florkiewicz RZ, Lukas RJ, Stachowiak MK. Puchacz E, et al. Brain Res. 1993 Apr 30;610(1):39-52. doi: 10.1016/0006-8993(93)91214-d. Brain Res. 1993. PMID: 8100172

• Nicotinic and muscarinic acetylcholine receptors are essential for the long-term response of tyrosine hydroxylase gene expression to chronic nicotine treatment in rat adrenal medulla.

  Yoshimura R, Xu L, Sun B, Tank AW. Yoshimura R, et al. Brain Res Mol Brain Res. 2004 Jul 26;126(2):188-97. doi: 10.1016/j.molbrainres.2004.04.007. Brain Res Mol Brain Res. 2004. PMID: 15249143

• Vitamin D status and gene transcription in immune cells.

  Morán-Auth Y, Penna-Martinez M, Shoghi F, Ramos-Lopez E, Badenhoop K. Morán-Auth Y, et al. J Steroid Biochem Mol Biol. 2013 Jul;136:83-5. doi: 10.1016/j.jsbmb.2013.02.005. Epub 2013 Feb 13. J Steroid Biochem Mol Biol. 2013. PMID: 23416105 Review.

• Regulation of tyrosine hydroxylase gene expression by transsynaptic mechanisms and cell-cell contact.

  Tank AW, Piech KM, Osterhout CA, Sun B, Sterling C. Tank AW, et al. Adv Pharmacol. 1998;42:25-9. doi: 10.1016/s1054-3589(08)60686-9. Adv Pharmacol. 1998. PMID: 9327837 Review. No abstract available.

Cited by

• Fok-I, Bsm-I, and Taq-I Variants of Vitamin D Receptor Polymorphism in the Development of Autism Spectrum Disorder: A Literature Review.

  Biswas S, Kanwal B, Jeet C, Seminara RS. Biswas S, et al. Cureus. 2018 Aug 29;10(8):e3228. doi: 10.7759/cureus.3228. Cureus. 2018. PMID: 30410834 Free PMC article. Review.

• Mitochondrial Agents for Bipolar Disorder.

  Pereira C, Chavarria V, Vian J, Ashton MM, Berk M, Marx W, Dean OM. Pereira C, et al. Int J Neuropsychopharmacol. 2018 Jun 1;21(6):550-569. doi: 10.1093/ijnp/pyy018. Int J Neuropsychopharmacol. 2018. PMID: 29596661 Free PMC article. Review.

• The effect of vitamin D on morphine preference in rats: Possible biochemical and DRD2-GDNF signaling.

  Saeedfar M, Ardjmand A, Alani B, Ghaderi A, Banafshe HR, Shahaboddin ME, Ghavipanjeh G. Saeedfar M, et al. Brain Behav. 2023 Feb;13(2):e2877. doi: 10.1002/brb3.2877. Epub 2023 Jan 11. Brain Behav. 2023. PMID: 36630182 Free PMC article.

• Vitamin D and neurodegenerative diseases.

  Wang W, Li Y, Meng X. Wang W, et al. Heliyon. 2023 Jan 12;9(1):e12877. doi: 10.1016/j.heliyon.2023.e12877. eCollection 2023 Jan. Heliyon. 2023. PMID: 36820164 Free PMC article. Review.

• Vitamin D Status and Parkinson's Disease.

  Barichella M, Garrì F, Caronni S, Bolliri C, Zocchi L, Macchione MC, Ferri V, Calandrella D, Pezzoli G. Barichella M, et al. Brain Sci. 2022 Jun 16;12(6):790. doi: 10.3390/brainsci12060790. Brain Sci. 2022. PMID: 35741675 Free PMC article. Review.

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Elsevier Science

• Medical

  • MedlinePlus Health Information