Spinal traumas: Some postoperative complications in experimental animals
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Abstract
Animals with severe spinal traumas show paraplegic syndrome and various somatic and autonomie dysfunctions. Of the various dysfunctions those related to hypothermia, bladder problems, and autophagia are of serious nature. The condition of animals with these complications deteriorates rapidly, and the animals are sacrificed for histological and pathological analyses. The findings show that the postoperative complications are related to the degree of severity of the trauma, and that 50–80% animals are lost due to these complications. Most of these animals are lost during the first two weeks after the surgery, and the remaining at later stages. Transplantation of neural tissue at the site of lesion does not ameliorate these postoperative complications and improve the survival rate of the animals.
Cited by (10)
Salmon fibrin treatment of spinal cord injury promotes functional recovery and density of serotonergic innervation
2012, Experimental Neurology
Citation Excerpt :
These tests showed that the responses of animals treated with salmon fibrin did not significantly differ from those of animals treated with human fibrin and untreated controls several months post injury (Fig. 6A), suggesting that while salmon fibrin-treated rats have improved locomotor and bladder functional recovery, the anatomical underpinnings responsible for recovery do not lead to greater mechanical allodynia. Rats with dorsal hemisection lesions sometimes exhibit autophagia (gnawing of the paws) that leads to significant tissue damage and is thought to be due to paresthesia, or numbness, of the paws (Das et al., 1989). Since treatment with salmon fibrin improved recovery of locomotor and bladder function (motor systems) we wondered whether salmon fibrin treatment would also affect sensory systems.
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Research supported by NIH Research Grant No. NS-08817.
Copyright © 1989 Published by Elsevier Inc.