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Hope IA, et al. (1988) | SGD

Reference: Hope IA, et al. (1988)

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Abstract

Derivatives of the yeast GCN4 transcription factor containing acidic regions of 35 to 40 amino acids fused directly to the DNA-binding domain are fully functional in vivo. High resolution deletion analysis and proteolytic mapping suggest that the activation region is a repeated structure composed of small units acting additively. Acidic character is a feature of the structural motif, possibly a dimer of alpha-helices from two GCN4 monomers, that may be important for interactions with the basic transcriptional machinery.

Reference Type
Journal Article | Research Support, U.S. Gov't, P.H.S.
Authors
Hope IA, Mahadevan S, Struhl K

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