MRC Laboratory of Molecular Biology
- ️Fri Oct 06 2023
About Us
The MRC Laboratory of Molecular Biology (LMB) is a research institute dedicated to the understanding of important biological processes at the levels of atoms, molecules, cells and organisms. In doing so, we provide knowledge needed to solve key problems in human health.
Our scientists tackle fundamental, often difficult and long-term research problems. The LMB has made revolutionary contributions to science, such as pioneering X-ray crystallography and electron cryo-microscopy (cryo-EM) to determine protein structures, the sequencing of DNA and the development of monoclonal antibodies. Twelve Nobel Prizes have been awarded for work carried out by LMB scientists.
The LMB also promotes the application and exploitation of our research findings, both by collaboration with existing companies and the founding of new ones, helping to advance medical research and the translation and application of knowledge.
The LMB provides an unsurpassed environment for both young and established researchers, with state-of-the-art facilities and a unique scientific culture. The LMB has always been very diverse, with a truly international outlook. We currently employ men and women from over 50 countries, and LMB alumni work in research organisations across the world.
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Latest News
LMB spinout TRIMTECH Therapeutics will develop targeted protein degraders to treat neurodegenerative conditionsLeo James co-founds new UK biotech company together with Will McEwan (UK DRI at Cambridge) leveraging the unique properties of TRIM21, discovered at the LMB. […]
Sortera Bio spins out of the LMB to pioneer new frontiers in biologics discoveryNew UK-based biotechnology company launched to realise therapeutic potential of Deep Screening technology developed by Ben Porebski and Philipp Holliger at the LMB. […]
Latest Publications
- Zinc finger homeobox-3 (ZFHX3) orchestrates genome-wide daily gene expression in the suprachiasmatic nucleus.
Bafna, A., Banks, G., Vasilyev, V., Dallmann, R., Hastings, MH., Nolan, PM.
Elife 14. (21st March 2025) - ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes.
Nixon-Abell, J., et al.
Nat Commun 16(1): 2814. (21st March 2025) - The conserved Spd-2/CEP192 domain adopts a unique protein fold to promote centrosome scaffold assembly.
Hu, L., et al.
Sci Adv 11(12): eadr5744. (21st March 2025) - Author Correction: Spatially resolved multiomics of human cardiac niches.
Kanemaru, K., et al.
Nature [Epub ahead of print]. (20th March 2025) - Elongator is a microtubule polymerase selective for polyglutamylated tubulin.
Planelles-Herrero, VJ., et al.
EMBO J 44(5): 1322-1353. (15th March 2025) - Regulation of acetyl-CoA biosynthesis via an intertwined acetyl-CoA synthetase/acetyltransferase complex.
Zheng, L., et al.
Nat Commun 16(1): 2557. (15th March 2025) - Cell envelope polysaccharide modifications alter the surface properties and interactions of with innate immune cells in a morphotype-dependent manner.
Lian, E., et al.
mBio : e0032225 [Epub ahead of print]. (14th March 2025)